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Cover image: Immunostaining of fixed polytene chromosomes with anti-holocarboxylase synthetase (HCS) serum showing HCS binding to distinct chromosomal sites in wild-type Drosophila melanogaster. See related article by Camporeale et al. on page 2735 (J. Nutr. 136:2735–2742, 2006). Copyright © 2006 American Society for Nutrition.