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Cover images: Illustration 1 (top): Copyright © 2005, Maria Luz Fernandez/Kristy West, Storrs, CT. Mechanisms by which PUFA modulate plasma lipids. See Fernandez & West, J. Nutr. 135: 2075–2078; Illustration 2 (middle): Copyright 2005, Bernhard Hennig, Lexington, KY. VCAM-1 expression in aortae of mice. See Reiterer et al., J. Nutr. 135: 2114–2118; Illustration 3 (bottom): Copyright © 2005, American Society for Nutritional Sciences. Electron micrographs of cardiac tissue from rats illustrating the general effects of dietary Cu content and feeding time on myocardial ultrastructure. See Li et al., J. Nutr. 135: 2130–2136.