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Cover images: Illustration 1 (top): Copyright © 2005, Richard Bruno, Corvallis, OR. Overall effects of cigarette smoking on vitamin E utilization. See Bruno and Traber, J. Nutr. 135: 671–674, 2005. Illustration 2 (middle): Copyright © 2005, Bettina Mittendorfer, St. Louis, MO. Sex-related factors that influence substrate metabolism. See Mittendorfter, J. Nutr. 135: 681–686, 2005. Illustration 3 (bottom): Copyright © 2005, Edward D. Harris, Texas A&M University, College Station, TX. Compounds in citrus fruits inhibit growth of brain cancer cells. See Poulose et al., J. Nutr. 135: 870–877, 2005.