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Cover images: Illustration 1 (top): Copyright © 2005, Xin Gen Lei and Wen-Hsing Cheng. The physiological importance and biochemical mechanism of GPX1 in protecting Se-deficient or Se-adequate mice against severe versus moderate oxidative stress. See Lei and Cheng, J. Nutr. 135: 2295–2298. Illustration 2 (middle): Copyright © 2005, American Society for Nutrition. Immunohistochemical localization of aquaporin-8 protein in the rat proximal colon. See Laforenza et al., J. Nutr. 135: 2329–2336. Illustration 3 (bottom): Copyright © 2005, American Society for Nutrition. Biotinylation of lysine-12 in histone H4 decreases rapidly and transiently in response to DNA double-strand breaks in JAr human choriocarcinoma cells. Panel a
staining of nuclei using DAPI; panel b
staining of K12-biotinylation of histone H4, using a site-specific antibody; panel c
staining of cytoplasmic compartment using rhodamine phalloidin; d
merged image. See Kothapalli et al., J. Nutr. 135: 2337–2342.