QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (Publish Ahead of Print[PDF]) All Versions of this Article: 139/7/1347    most recent jn.109.104471v1 Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Google Scholar Articles by Raff, M. Articles by Mandrup, S. PubMed PubMed Citation Articles by Raff, M. Articles by Mandrup, S.

---

Nutrition and Disease

Conjugated Linoleic Acids Reduce Body Fat in Healthy Postmenopausal Women^1,2,3

⁴ Department of Human Nutrition, Faculty of Life, University of Copenhagen, Frederiksberg 1958, Denmark ⁵ Department of Endocrinology and Metabolism C, Aarhus University Hospital, DK-8000 Aarhus C, Denmark ⁶ Biochemistry and Nutrition Group, BioCentrum-DTU, Technical University of Denmark, Lyngby 2800, Denmark ⁷ Parker Institute, Musculoskeletal Statistics Unit, Frederiksberg Hospital, Frederiksberg C 2000, Denmark ⁸ Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense 5000, Denmark

Isomers of conjugated linoleic acids (CLA) reduce fat mass (FM) and increase insulin sensitivity in some, but not all, murine studies. In humans, this effect is still debatable. In this study, we compared the effect of 2 CLA supplements on total and regional FM assessed by dual energy X-ray absorptiometry, changes in serum insulin and glucose concentrations, and adipose tissue (AT) gene expression in humans. In a double-blind, parallel, 16-wk intervention, we randomized 81 healthy postmenopausal women to 1) 5.5 g/d of 40/40% of cis9,trans11-CLA (c9,t11-CLA) and trans10,cis12-CLA (t10,c12-CLA) (CLA-mix); 2) cis9, trans11-CLA (c9,t11-CLA); or 3) control (olive oil). We assessed all variables before and after the intervention. The CLA-mix group had less total FM (4%) and lower-body FM (7%) than the control (P = 0.02 and < 0.001, respectively). Post hoc analyses showed that serum insulin concentrations were greater in the CLA-mix group (34%) than the control group (P = 0.02) in the highest waist circumference tertile only. AT mRNA expression of glucose transporter 4, leptin, and lipoprotein lipase was lower, whereas expression of tumor necrosis factor- was higher in the CLA-mix group than in the control group (P < 0.04). In conclusion, a 50:50 mixture of c9,t11- and t10,c12-CLA isomers resulted in less total and lower-body FM in postmenopausal women and greater serum insulin concentrations in the highest waist circumference tertile. Future research is needed to confirm the insulin desensitizing effect of the CLA mixture and the effect on the mRNA expression of adipocyte-specific genes in humans.

^* To whom correspondence should be addressed. E-mail: mrf{at}life.ku.dk.

Manuscript received 27 January 2009. Initial review completed 13 March 2009. Revision accepted 14 May 2009.