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Nutritional Epidemiology

Higher Intakes of Vegetables and Vegetable-Related Nutrients Are Associated with Lower Endometrial Cancer Risks¹

² Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY 14263 ³ Department of Social and Preventive Medicine, University at Buffalo, Buffalo, NY 14214

A limited number of studies have investigated diet in association with endometrial cancer (EC). We examined the association between intakes of selected food groups and nutrients with EC risk among 541 women with histologically confirmed EC and 541 women with an intact uterus and noncancer diagnoses seen at Roswell Park Cancer Institute between 1982 and 1998. Self-reported dietary and other epidemiologic data were collected by questionnaire. Unconditional logistic regression was used to estimate odds ratios (OR) and 95% CI, adjusting for age, BMI, hormone replacement therapy use, cigarette smoking, lifetime duration of menstruation, and total energy intake. We observed significant inverse associations for women in the highest vs. lowest quartiles of intake of total vegetables (OR, 0.51; 95% CI, 0.34–0.75), vitamin E (OR, 0.44; 95% CI, 0.27–0.70), dietary fiber (OR, 0.60; 95% CI, 0.39–0.94), β-carotene (OR, 0.55; 95% CI, 0.37–0.82), lutein (OR, 0.52; 95% CI, 0.34–0.78), and folate (OR, 0.57; 95% CI, 0.36–0.91). Our results support that vegetables and related nutrients are associated with decreased risk of EC.

^* To whom correspondence should be addressed. E-mail: susan.mccann{at}roswellpark.org.

Manuscript received 22 September 2008. Initial review completed 7 October 2008. Revision accepted 3 November 2008.