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Structural Changes in Rabbit Oral Epithelium Caused by Zinc Deficiency1,2,

Charles E. Joseph, Shahid H. Ashrafi and John P. Waterhouse

Department of Oral Pathology, College of Dentistry, University of Illinois at the Medical Center, Chicago, IL 60612

We report the successful establishment of zinc deficiency in rabbits by dietary means. The soybean protein of a standard rabbit diet was replaced by egg albumin. Weanling, New Zealand white rabbits, were fed a low zinc diet containing 1.5 µg Zn/g of diet. Zinc-deficient rabbits showed stunted growth, weight loss, altered posture, partial alopecia and crusting of skin. Structural alterations in oral epithelium of the zinc-deficient rabbits included in the tongue flattened filiform papillae showing parakeratosis, in the cheek parakeratosis of the normally nonkeratinized epithelium and hyperplasia of the lip epidermis.

KEY WORDS: • zinc deficiency • rabbits • oral epithelium • parakeratosis

1 This investigation was supported by USPHS research grant DE 05128-02 from the National Institute for Dental Research.

2 Portions of this investigation were presented at the 1980 General Session of the American Association for Dental Research, Los Angeles, CA, (abs. 664).

Manuscript received 9 June 1980.


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