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Schwab U., Törrönen A., Meririnne E., Saarinen M., Alfthan G., Aro A., Uusitupa, M. Orally administered betaine has an acute and dose-dependent effect on serum betaine and plasma homocysteine concentrations in healthy humans. J. Nutr. 136:34–38.

The urinary excretion if betaine seemed to accelerate with an increase in the betaine dose, whereas the excretion of DMG was more constant. The urinary excretion of betain was 0.14 ± 0.07 mmol at the 1-g dose, 0.86 ± 0.75 mmol at the 3-g dose, and 3.35 ± 2.10 mmol at the 6-g dose. The respective values for DMG were 0.14 ± 0.06, 0.23 ± 0.10, and 0.47 ± 0.26 mmol, respectively.

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