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Supplement: Significance of Garlic and Its Constituents in Cancer and Cardiovascular Disease

Significance of Garlic and Its Constituents in Cancer and Cardiovascular Disease

This supplement issue of The Journal of Nutrition is devoted to the results of an International Research Symposium held at Georgetown University, April 9–11, 2005, entitled, "Significance of Garlic and Its Constituents in Cancer and Cardiovascular Disease". It brought together scientists active in the field from all over the world. There are many new findings on garlic in medicine that needed to be discussed and evaluated.

The symposium began with considerations of the role of garlic in clinical medicine, the active principles contained in garlic, and the metabolism of garlic and its derivatives. The European perspective on garlic and its control was also introduced. The subject then shifted to the cardiovascular effects of garlic as viewed from the field of epidemiology and then to new information on the inhibition of coronary artery plaque by garlic. A similar group of presentations was devoted to cancer, stressing the preventive and therapeutic roles of garlic and its derivatives. Both preclinical data on garlic and clinical data from a large study in China were included in the presentations.

The mechanisms of action of garlic in cardiovascular diseases were evaluated in relation to homocysteine metabolism, endothelial function, cholesterol synthesis, and oxidation, as well as to platelet aggregation. Further clinical aspects of treatment with garlic in sickle cell anemia and type II diabetes are strongly related to its cardiovascular effects. In oncology, animal models have been utilized to elucidate mechanisms of cancer chemoprevention and antiproliferative actions of garlic. The relationship of garlic, a seleniferous plant, to selenium metabolism and selenoproteins was explored.

It is important to stress that all the papers in this symposium issue were peer-reviewed before being included. The act of presenting a paper at the symposium did not automatically assure its publication in this volume.

By publishing the symposium in a major journal, thereby releasing the results to a large scientific audience, the impact of the new findings is greatly expanded. The conference in its entirety served to promote interactions among scientists in different disciplines in order to gain from each other's knowledge and experience. We are firmly committed to encouraging basic science–clinical science interactions. These interactions serve to advance translational research, in which results from basic science are tested for their efficacy, toxicity, and feasibility for application to the prevention and treatment of disease in human beings.

The editors are deeply indebted to the sponsors of the symposium for their support and to each of the participants for the timely and thorough reports that constitute this volume.

This Article Full Text (PDF) Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Rivlin, R. S. Articles by Amagase, H. Search for Related Content PubMed Articles by Rivlin, R. S. Articles by Amagase, H.