![[Feedback]](/icons/banner/feedbackACT.gif){kind=icon}
![[For Subscribers]](/icons/banner/subscriberACT.gif){kind=icon}
![[Archive]](/icons/banner/archiveACT.gif){kind=icon}
![[Search]](/icons/banner/searchACT.gif){kind=icon}
![[Contents]](/icons/banner/tocACT.gif){kind=icon}
|
|
|
|
|
||
The Center for Genetics, Nutrition and Health, Washington, DC
2To whom correspondence should be addressed. E-mail: cgnh{at}bellatlantic.net
 |
ABSTRACT |
|---|
 TOP ABSTRACT INTRODUCTIONThe diet of Crete...Bioprotective nutrients and...EFA and cancerImplementation of the diet...LITERATURE CITED |
|---|
KEY WORDS: • diet of Crete • (n-3) fatty acids • wild plants • antioxidants • cancer • (n-6) fatty acids
|
INTRODUCTION |
|---|
|
TOPABSTRACTINTRODUCTIONThe diet of Crete...Bioprotective nutrients and...EFA and cancerImplementation of the diet...LITERATURE CITED |
|---|
–4
). Our genetic profile has not changed over the past 10,000 y, whereas major changes have taken place in our food supply and in energy expenditure and physical activity (5
–17
). Today industrialized societies are characterized by the following: 1) an increase in energy intake and decrease in energy expenditure; 2) an increase in saturated fat, (n-6) fatty acids and trans fatty acids and a decrease in (n-3) fatty acid intake; 3) a decrease in complex carbohydrates and fiber intake; 4) an increase in cereal grains and a decrease in fruit and vegetable intake; and 5) a decrease in protein, antioxidant and calcium intake (5
–17
). Furthermore, the ratio of (n-6) to (n-3) fatty acids is 16.74:1, whereas during evolution it was 2–1:1 (Table 1
, Fig. 1
).;T1,F1>
|
|
), which is not surprising because the countries along the Mediterranean basin have different religions, economic and cultural traditions and diets. Diets are influenced by religious habits, that is, Muslims do not eat pork or drink wine and other alcoholic drinks, whereas Greek Orthodox populations usually do not eat meat on Wednesdays and Fridays but drink wine, and so on. Although Greece and the Mediterranean countries are usually considered to be areas of medium-high death rates (14.0–18.0 per 1000 inhabitants), death rates on the island of Crete have been below this level continuously since before 1930 (19
). No other area in the Mediterranean basin has had as low a death rate as Crete, according to data compiled by the United Nations in their demographic yearbook for 1948. It was 11.3–13.7 per 1000 inhabitants before World War II and 
10.6 in 1946–1948 (19
). Cancer and heart disease caused almost three times as many deaths proportionally in the United States as in Crete (19
). The diet of Crete represents the traditional diet of Greece before 1960. The Seven Countries Study was the first to establish credible data on cardiovascular disease prevalence rates in contrasting populations (United States, Finland, The Netherlands, Italy, former Yugoslavia, Japan and Greece), with differences found on the order of 5- to 10-fold in coronary heart disease (20
). In 1958, the field work started in Dalmatia in the former Yugoslavia. From the inception of the research program, an important focus was on the diet and its possible relationship to the etiology of coronary heart disease. The 5-y follow-up found favorable all-cause death rates in Greece, Japan and Italy compared with the other areas, as well as a lower incidence rate of coronary disease (20
). The Seven Countries Study was designed to investigate relationships between diet and cardiovascular disease, primarily described in terms of the fatty acid composition of the diet.
This paper describes the characteristics of the traditional diet of Greece before 1960 as exemplified by the diet of Crete and its relationship to cancer. The diet of Crete or the traditional diet of Greece resembles the Paleolithic diet in terms of fiber, antioxidants, saturated fat, monounsaturated fat and the ratio of (n-6) to (n-3) fatty acids (Table 1)
(21
). The Lyon Heart Study (22
–25
) and subsequently the study of Singh et al. (26
,27
) support the importance of having a diet consistent with human evolution. Western diets today deviate from the Paleolithic diet and are associated with high rates of cardiovascular disease, diabetes, obesity and cancer.
|
The diet of Crete and its relation to cardiovascular disease and cancer |
|---|
|
TOPABSTRACTINTRODUCTIONThe diet of Crete...Bioprotective nutrients and...EFA and cancerImplementation of the diet...LITERATURE CITED |
|---|
–35
) and the essentiality of (n-3) fatty acids, particularly docosahexaenoic acid [DHA,3
22:6(n-3)], for the development of retina and brain of the premature infant. It therefore became important to investigate the (n-3) fatty acid composition of diets that have been shown to be associated with a decreased rate of cardiovascular disease and cancer. Such an opportunity presented itself in the diet of Crete (21
).
The results of the Seven Countries Study are interesting because they show that the population of Crete had the lowest rates of cardiovascular disease and cancer, followed by the population of Japan (20
). The investigators concluded that the reason for these low rates must be the high olive oil intake and the low saturated fat intake of the Mediterranean diet. The fact that Crete had a high fat diet (37% of energy from fat) and Japan had a low fat diet (11% of energy from fat) was not discussed extensively nor were any other fatty acids considered despite the fact that the people of Crete ate 30 times more fish than did the U.S. population. Furthermore, the people of Crete ate a large amount of vegetables (including wild plants), fruits, nuts and legumes, all rich sources of folate, calcium, glutathione, antioxidants, vitamins E and C and minerals. In addition, because the meat came from animals that grazed rather than being fed grain, it contained (n-3) polyunsaturated fatty acids (PUFA) as did the milk and milk products, such as cheese (Table 2
). The population of Crete eats snails during Lent and throughout the year. Renaud (Serge Renaud, INSERM, Bordeaux, France, personal communication) has shown that the snails of Crete and Greece contain more (n-3) fatty acids and less (n-6) fatty acids than do the snails of France.
|
–38
). Purslane, a commonly eaten plant (Table 3
), is rich in 
-linolenic acid [LNA, 18:3(n-3); 400 mg/100 g] as well as in vitamin E (12 mg/100 g), vitamin C (27 mg/100 g) and glutathione (15–20 mg/100 g) (37
). In Crete and Greece, purslane is eaten fresh in salads, soups and omelets or cooked with poultry; during the winter months, dried purslane is used in soups and vegetable pies and as a tea for sore throat and earache. It is highly recommended for pregnant and lactating women and for patients with diabetes.
|
). In the Greek countryside, chickens wander on farms, eat grass, purslane, insects, worms and dried figs, all good sources of (n-3) fatty acids. Table 4
shows the composition of the Ampelistra (Greek) egg (39
,40
). It has a ratio of (n-6) to (n-3) of 1.3 whereas the USDA egg has a ratio of 19.4. As a result, noodles made with milk and eggs in Greece also contain (n-3) fatty acids.
|
). Although these studies were carried out between 1984 and 1986, further analyses of blood specimens from the Seven Countries Study were published in 1993 by Sandker et al. (42
), indicating that the serum cholesteryl esters of the population in Crete had threefold more LNA than did the population of Zutphen (Table 5
). Similar data indicated that the Japanese population also had higher concentrations of (n-3) fatty acids than did the population of Zutphen. Here then was the missing link. It was the higher concentrations of (n-3) fatty acids that added protection against cardiovascular disease, not only the olive oil, wine, fruits and vegetables of the "typical" Mediterranean diet.
|
(42
).
Renaud et al. (43
) had been working with LNA and had shown that it decreases platelet aggregation. Everything seemed to fall into place in terms of defining the characteristics of the diet of the population of Crete. Their diet was very similar to the Paleolithic diet in composition (Table 1)
. The diet was low in saturated fat, balanced in the essential fatty acids [EFA; (n-6) and (n-3)], very low in trans fatty acids and high in vitamins E and C. This diet formed the basis of the diet used by de Lorgeril and Renaud in their now famous Lyon Heart Study (22
–25
). The Lyon Heart Study was a prospective randomized, single-blind secondary prevention trial that compared the effects of a modified Crete diet enriched with LNA with those of a Step I American Heart Association diet. The study showed a decrease in death rate by 70% in the experimental group and clearly showed that a modified Crete diet low in butter and meats such as deli products but high in fish and fruits and vegetables and enriched with LNA is more efficient than the American Heart Association or similar prudent diets in the secondary prevention of coronary events and total deaths (22
). The same subjects were followed for 5 y. At 4 y of follow-up, de Lorgeril et al. (24
) reported that the reduction of risk in the experimental subjects compared with control subjects was 56% (P = 0.03) for total deaths and 61% (P = 0.05) for cancers, indicating that a modified diet of Crete was associated with lower risk for coronary heart disease and cancer.
|
Bioprotective nutrients and mechanisms |
|---|
|
TOPABSTRACTINTRODUCTIONThe diet of Crete...Bioprotective nutrients and...EFA and cancerImplementation of the diet...LITERATURE CITED |
|---|
–25
). Wine, fruits, vegetables (particularly wild plants) and olive oil provide high amounts of resveratrol, glutathione, vitamin C, vitamin E, lycopene, ß-carotene, polyphenols and other antioxidants (44
–48
). The importance of a Cretan-type diet, rich in LNA from vegetables and fruits and eicosapentaenoic acid [EPA, 20:5(n-3)] and DHA from fish, was demonstrated in the Diet and Reinfarction Trial (or DART) (49
), the Lyon Heart Study (22
–25
), the study by Singh et al. (26
,27
) and the most recent Gruppo Italiano per lo Studio della Sopravivenza nell’Infarto Miocardico (GISSI)-Prevenzione trial (50
).
Olive oil is high in the monounsaturated fatty acid oleic acid [18:1, (n-9)] and low in saturated and (n-6) fatty acids; it does not compete with the desaturation and elongation of LNA nor with the incorporation of (n-3) fatty acids into the red cell membrane phospholipids, providing an additional benefit to the functions of (n-3) fatty acids (5
). Furthermore, the (n-6) to (n-3) ratio in the Greek diet is between 2:1 and 1:1, which is very close to the dietary ratio of the Paleolithic diet (Table 1)
. The beneficial effects of such a ratio and their importance in normal growth and development (51
–53
) and in the prevention and management of cardiovascular disease, hypertension, diabetes, arthritis and possibly cancer have been reviewed extensively (5
,28
–35
,54
57
).
Because Greeks have a cultural dislike for animal fats, the saturated fat intake of the Greek diet is lower than that for other Mediterranean and Western diets (19
). The Greek diet, then, is characterized by being moderate in fat (35%), low in saturated fat (7–8%), high in monounsaturated fat and balanced in the (n-6) and (n-3) EFA. The content of antioxidants, phytoestrogens and other phytochemicals is much higher than in other diets of the people around the Mediterranean basin because Greeks continue to eat wild greens that are rich sources of LNA, vitamin C, vitamin E and glutathione (36
–38
). The beneficial effects of the various compounds found in the vegetables and fruits eaten by Greeks have been shown to have hypoglycemic, hypocholesterolemic and antitumor properties in animal experiments (44
). Even today, the mortality from breast cancer is lower in Greece than in the United States, Japan and Europe (58
). Finally, the Lyon Heart Study based on the modified diet of Crete described by de Lorgeril et al. (22
–25
) clearly showed cardioprotective and anticancer effects in a French population, indicating that such a diet is not only palatable but can be adapted to other populations. Furthermore, one could consider that the traditional diet of Greece even in its present form is the diet that is closer than the diets of other developed countries to the diet on which humans evolved (Fig. 1)
(18
).
|
EFA and cancer |
|---|
|
TOPABSTRACTINTRODUCTIONThe diet of Crete...Bioprotective nutrients and...EFA and cancerImplementation of the diet...LITERATURE CITED |
|---|
).
There are two families of EFA, the (n-6) and (n-3) families. The principal EFA in the U.S. diet is LA, an (n-6) fatty acid. One of the main functions of EFA in the body is as a precursor for eicosanoids, which are mediators of inflammation and cellular growth. EFA are converted to prostaglandins by cyclooxygenases and to leukotrienes (LT) by lipoxygenases. Arachidonic acid [(AA); 20:4(n-6)] and EPA, an (n-3) fatty acid, compete for cyclooxygenases and lipoxygenases, resulting in the production of eicosanoids with opposing effects. In general, AA-derived eicosanoids, such as the 2-series prostanoids and 4-series LT, have proinflammatory effects, whereas EPA-derived eicosanoids, such as the 3-series prostanoids and 5-series LT, have anti-inflammatory effects. There is competition and opposition of EFA in the body; thus research has been conducted to determine the importance of the (n-6) to (n-3) ratio rather than the absolute level of either class of PUFA in cancer prevention (5
,59
).
Animal studies and cell lines.
In animal studies (rats) LA increases the size and number of tumors, whereas fish oil [containing the (n-3) fatty acids EPA and DHA] decreases both (60
,61
). Studies in rats suggest that inhibitors of prostaglandin synthesis, such as indomethacin and flurbiprofen, can inhibit mammary carcinogenesis. The prostaglandin-inhibitory effect of fish oils has been tested in animal tumor systems by many investigators, and the studies provide evidence that at optimal levels, (n-3) fatty acids may be useful as inhibitory agents in some colon, lung, mammary, pancreatic and prostatic tumors in experimental animals, whereas LA supports tumor growth (62
). Studies in cell lines and animals appear to support the epidemiologic evidence concerning the protective role of a ratio of (n-6) to (n-3) of < 2:1 against the development of mammary cancer and to provide evidence that (n-3) fatty acids could have the potential to be used as an adjuvant therapy to prevent recurrence and metastases of mammary cancer (59
).
Epidemiologic studies.
The effects of (n-6) and (n-3) fatty acids on the growth and progression of tumors are different. Epidemiologic studies in humans during the past two decades have demonstrated that the consumption of fish oil protects against the development of cancers, especially mammary cancer (63
). Klein et al. (64
) showed that low LNA levels in mammary adipose tissue were inversely correlated with increased mammary cancer risk in women. In patients with prostate cancer, fish intake was inversely related to cancer (65
).
Mechanisms.
Recent data demonstrated the effectiveness of n-3 EFA in regulating growth, progression, metastasis and postexcision recurrence of mammary tumors in murine models. Furthermore, there is evidence that EFA influence [(n-6) stimulate whereas (n-3) suppress the pathway] the epidermal growth factor receptor/mitogen-activated protein kinase pathway, targeting many of the same components as drugs under development (59
).
The data suggest that the most important aspect of EFA in the prevention of mammary cancer is the ratio of (n-6) to (n-3) fatty acids rather than the absolute concentration of either (59
). Research data indicate that a ratio of 1:1 or 2:1 protects most against the development and growth of mammary cancer. Western diets have a ratio of 10–20:1, or 16.74 (17
). Clearly, these data suggest that further research into the usefulness of dietary manipulation of EFA for the prevention or adjuvant treatment of mammary cancer, as well as continued research into the mechanisms of EFA in mammary tumor development, is warranted. Cyclooxygenase-2 is overexpressed in cancer of the colon (66
). Recently, DeCaterina and Habib (R. DeCaterina, G. d’Annunzio University, Chieti, and CNR Institute of Clinical Physiology, Pisa, Italy, & A. Habib, Hopital Lariboisière, Paris, unpublished observations, 2001) showed that DHA down-regulates the expression of cyclooxygenase-2 and induces apoptosis (67
–72
).
Dietary supplementation with (n-3) fatty acids in clinical trials.
Dietary supplementation with (n-3) fatty acids has been tested in several clinical trials. In pancreatic cancer, a malignancy associated with a persistent inflammatory response and increased energy expenditure, 3 mo of dietary supplementation with a median of 12 g/d fish oil (EPA 18% and DHA 12%) led to a significant median weight gain of 0.3 kg/mo, accompanied by a temporary but significant reduction in acute-phase protein production and by stabilization of resting energy expenditure (73
). Gogos et al. (74
) randomly assigned 60 patients with generalized solid tumors to dietary supplementation with either fish oil or placebo daily until death. The (n-3) fatty acids had an impressive immunomodulating effect, as reflected by the ratio of T-helper cells to T-suppressor cells in the subgroup of malnourished patients. There were no significant differences in cytokine production among the various groups. In addition, (n-3) fatty acids prolonged the survival of all patients (74
). These stimulating results warrant further clinical trials to establish the exact benefits and limitations of (n-3) fatty acid supplementation in cancer patients.
Selenium.
A randomized clinical trial in the United States showed that selenium supplementation (200 µg/d) decreased the incidence of prostate, lung and colorectal cancer over a mean follow-up of 4.5 y (75
). An inverse association was reported between advanced prostate cancer and toenail selenium concentrations, a surrogate of long-term selenium intake (76
). The Greek diet, rich in marine products, provides adequate amounts of selenium. Octopus, the Greek national appetizer, contains 90 µg selenium/100 g. In both the Lyon study and the U.S. selenium trials, the benefits in terms of cancer became apparent within 3–4 y. In animal models, selenium has been shown to interfere with carcinogenesis through several possible mechanisms (77
).
Resveratrol.
Resveratrol (3,4',5-trihydroxystilbene) is a naturally occurring polyphenolic phytoalexin found in wine and medicinal plants of the Polygonum species (Polygonaceae). Resveratrol inhibits lipogenesis from palmitate in the liver and adipose tissue (78
), inhibits the formation of lipoxygenase products (LTB4 and LTC4) and inhibits AA platelet aggregation (79
–81
). Resveratrol and its derivatives have been further shown to strongly inhibit the degranulation of polymorphonuclear leukocytes (81
), and resveratrol inhibits tumor growth and causes apoptosis as a cancer chemopreventive agent (82
–89
). The antitumor and antimetastatic activities of resveratrol may be due to the inhibition of DNA synthesis in metastatic Lewis lung carcinoma cells, neovascularization induced by these cells and tube formation (angiogenesis) of human umbilical vein endothelial cells by resveratrol (90
).
Glutathione.
The protective role of glutathione as an antioxidant and detoxifying agent has been demonstrated in various clinical studies. It is a ubiquitous compound that is synthesized rapidly in the liver, kidney and other tissues, including the gastrointestinal tract. In animal cells, glutathione acts as a substrate for glutathione peroxidase, which reduces lipid peroxides that are formed from PUFA in the diet, and as a substrate for glutathione S-transferase, which conjugates electrophilic compounds. Recent studies showed that glutathione obtained from the diet is directly absorbed by the gastrointestinal tract and thus dietary glutathione can readily increase the antioxidant status in humans (91
). Dietary glutathione, in addition to that supplied by the bile, may be used by the small intestine to decrease the absorption of peroxides. These results indicate that in intact animals, lumenal glutathione is available for use by the intestinal epithelium to metabolize peroxides and other reactive species and to prevent their transport to other tissues.
Dietary glutathione occurs in highest amounts in fresh meats and in moderate amounts in some fruits and vegetables; it is absent or found only in small amounts in grains and dairy products (92
). Only fresh asparagus (28.3 mg/100 g) and fresh avocado (27.7 mg/100 g) were higher than purslane in glutathione content in a study by the National Cancer Institute that determined the glutathione content of 98 food items that contribute 90% or more of energy, dietary fiber and 18 major nutrients to the U.S. diet (92
–94
).
The potential health effects of dietary intake of glutathione in humans are shown in Table 6
(90
,95
–103
). In a recent study by Flagg et al. (104
), plasma glutathione concentrations varied widely in humans and were influenced by sex and age (increased with age in men but decreased with age and were lower in women who used estrogen-containing contraceptives).
|
–108
). Considerable variations in levels of glutathione have been reported by different studies recording thiol levels in a variety of plant species. This may be due in part to the use of different analytical techniques and because glutathione levels vary both diurnally (109
,110
) and with developmental and environmental factors (111
–113
). Taking into account these considerations, the levels of glutathione found in purslane, 14.81 ± 0.78 mg/100 g fresh weight, were in the range of those reported for other plant species but significantly higher than the level of 9.65 ± 0.62 mg/100 g fresh weight for spinach (Table 7
) (38
). Glutathione was present in significantly greater amounts in chamber-grown purslane relative to wild plants, which may reflect a difference in the developmental stage of the plants analyzed or in the environmental conditions experienced.
|
|
Implementation of the diet of Crete |
|---|
|
TOPABSTRACTINTRODUCTIONThe diet of Crete...Bioprotective nutrients and...EFA and cancerImplementation of the diet...LITERATURE CITED |
|---|
). Figure 2
is the Greek Column Food Guide based on the diet of Crete (114
). The visualization of this food guide in the form of a Greek column includes the concepts of genetic variation and nutrition and a balanced energy intake and energy expenditure; it is based on foods, not food groups. Although it excludes certain foods made with hydrogenated oils, it does not restrict the intake of naturally occurring foods. It also takes into consideration moderation, variety and proportionality. Dietary guidelines shown in Table 8
provide further information on how to implement the diet of Crete (21
).
|
|
The results of the Seven Countries Studies and the Lyon Heart Study based on a modified diet of Crete indicate that a Paleolithic-type diet such as the traditional Greek diet balanced in (n-6) and (n-3) fatty acids and rich in vitamins C and E (fruits and vegetables) is associated with decreased rates of heart disease and cancer more so than any other diet or drug intervention.
What appears to be so special about the Greek diet relative to the other Mediterranean diets is the content of bioprotective nutrients, specifically the following: 1) a more balanced intake of EFA from vegetable, animal and marine sources; a ratio of (n-6) to (n-3) fatty acids of 2:1 instead of the 15:1 in Western and Northern Europe and 16.74:1 in the United States; and 2) a diet rich in antioxidants, i.e., high amounts of vitamin C, vitamin E, ß-carotene, glutathione, resveratrol, selenium, phytoestrogens, folate, and other phytochemicals from green leafy vegetables; phenolic compounds from wine and olive oil; high intakes of tomatoes, onions, garlic and herbs, especially oregano, mint, rosemary, parsley and dill, which contain lycopene, allyl thiosulfinates, salicylates, carotenoids, indoles, monoterpenes, polyphenols, flavonoids and other phytochemicals used in cooking vegetables, meat and fish.
Such a dietary pattern has been shown to be beneficial to health because it is associated with a reduced risk of cardiovascular disease and cancer. The time has come for the initiation of intervention trials that will test the effect of specific dietary patterns in the prevention and management of patients with cancer.
|
FOOTNOTES |
|---|
3 Abbreviations used: AA, arachidonic acid; DHA, docosahexaenoic acid; EFA, essential fatty acids; EPA, eicosapentaenoic acid; LA, linoleic acid; LNA, -linolenic acid; LT, leukotrienes; PUFA, polyunsaturated fatty acids.
|
LITERATURE CITED |
|---|
|
TOPABSTRACTINTRODUCTIONThe diet of Crete...Bioprotective nutrients and...EFA and cancerImplementation of the diet...LITERATURE CITED |
|---|
1. Simopoulos, A. P. & Childs, B. (1990) Genetic variation and nutrition. World Rev. Nutr. Diet 63:1-300.
2. Simopoulos, A. P. & Nestel, P. J. (1997) Genetic variation and dietary response. World Rev. Nutr. Diet. 80:1-170.[Medline]
3. Simopoulos, A. P. (1999) Evolutionary aspects of nutrition and health: diet, exercise, genetics and chronic disease. World Rev. Nutr. Diet. 84:1-146.[Medline]
4. Simopoulos, A. P., Herbert, V. & Jacobson, B. (1995) The Healing Diet 1995 Macmillan New York, NY. .
5. Simopoulos, A. P. (1991) Omega-3 fatty acids in health and disease and in growth and development. Am. J. Clin. Nutr. 54:438-463.
6. Eaton, S. B. & Konner, M. (1985) Paleolithic nutrition. A consideration of its nature and current implications. N. Engl. J Med. 312:283-289.[Medline]
7. Eaton, S. B., Konner, M. & Shostak, M. (1988) Stone agers in the fast lane: chronic degenerative diseases in evolutionary perspective. Am. J. Med. 84:739-749.[Medline]
8. Eaton, S. B., Eaton, S. B., III, Sinclair, A. J., Cordain, L. & Mann, N. J. (1998) Dietary intake of long-chain polyunsaturated fatty acids during the Paleolithic. World Rev. Nutr. Diet. 83:12-23.[Medline]
9. Simopoulos, A. P. (1998) Overview of evolutionary aspects of 
3 fatty acids in the diet. World Rev. Nutr. Diet. 83:1-11.[Medline]
10. Sanders, T.A.B. (2000) Polyunsaturated fatty acids in the food chain in Europe. Am. J. Clin. Nutr. 71(suppl.):S176-S178.
11. Sugano, M. & Hirahara, F. (2000) Polyunsaturated fatty acids in the food chain in Japan. Am. J. Clin. Nutr. 71(suppl.):S189-S196.
12. Simopoulos, A. P. (1999) Genetic variation and evolutionary aspects of diet. Papas, A. M. eds. Antioxidant Status, Diet, Nutrition and Health 1999:65-88 CRC Press Boca Raton, FL. .
13. Simopoulos, A. P. (1999) Evolutionary aspects of omega-3 fatty acids in the food supply. Prostaglandins Leukot. Essent. Fatty Acids. 60:421-429.[Medline]
14. Simopoulos, A. P. (1989) Nutrition and fitness. J. Am. Med. Assoc. 261:28.
15. Simopoulos, A. P. & Pavlou, K. N. (2001) Nutrition and fitness. Diet, genes, physical activity and health. World Rev. Nutr. Diet. 89:1-192.[Medline]
16. Simopoulos, A. P. & Pavlou, K. N. (2001) Nutrition and fitness. Metabolic studies in health and disease. World Rev. Nutr. Diet. 90:1-198.
17. Simopoulos, A. P. (2001) Evolutionary aspects of diet and essential fatty acids. World Rev. Nutr. Diet. 88:18-27.[Medline]
18. Simopoulos, A. P. & Visioli, F. (2000) Mediterranean diets. World Rev. Nutr. Diet. 87:1-184.[Medline]
19. Allbaugh, L. G. (1953) Crete: A Case Study of an Underdeveloped Area 1953 Princeton University Press Princeton, NJ. .
20. Keys, A. (1970) Coronary heart disease in seven countries. Circulation 41(suppl.):1-211.
21. Simopoulos, A. P. & Robinson, J. (1999) The Omega Diet. The Lifesaving Nutritional Program Based on the Diet of the Island of Crete 1999 HarperCollins New York, NY. .
22. de Lorgeril, M., Renaud, S., Mamelle, N., Salen, P., Martin, J. L., Monjaud, I., Guidollet, J., Touboul, P. & Delaye, J. (1994) Mediterranean alpha-linolenic acid-rich diet in the secondary prevention of coronary heart disease. Lancet 343:1454-1459.[Medline]
23. Renaud, S., de Lorgeril, M., Delaye, J., Guidollet, J., Jacquard, F., Mamelle, N., Martin, J. L., Monjaud, I., Salen, P. & Touboul, P. (1995) Cretan Mediterranean diet for prevention of coronary heart disease. Am. J. Clin. Nutr. 61(suppl.):1360S-1367S.[Abstract]
24. de Lorgeril, M., Salen, P., Martin, J. L., Monjaud, I., Boucher, P. & Mamelle, N. (1998) Mediterranean dietary pattern in a randomized trial. Prolonged survival and possible reduced cancer rate. Arch. Intern. Med. 158:1181-1187.
25. de Lorgeril, M. & Salen, P. (2000) Modified Cretan Mediterranean diet in the prevention of coronary heart disease and cancer. Simpoulos, A. P. Visioli, F eds. Mediterranean Diets 87:1-23 Karger Basel, Switzerland. .
26. Singh, R. R., Rastogi, S. S., Verma, R., Laxmi, B., Singh, R., Ghosh, S. & Niaz, M. A. (1992) Randomised controlled trial of cardioprotective diet in patients with recent acute myocardial infarction: results of a one year follow-up. Br. Med. J. 304:1015-1019.
27. Singh, R. B., Niaz, M. A., Sharma, J. P., Kumar, R., Rastogi, V. & Moshiri, M. (1997) Randomized, double-blind, placebo-controlled trial of fish oil and mustard oil in patients with suspected acute myocardial infarction: the Indian experiment of infarct survival–4. Cardiovasc. Drugs Ther. 11:485-491.[Medline]
28. Simopoulos, A. P. Kifer, R. R. Martin, R. E. eds. Health Effects of Polyunsaturated Fatty Acids in Seafoods 1986 Academic Press Orlando, FL. .
29. Galli, C. & Simopoulos, A. P. (1989) Dietary 3 and 6 Fatty Acids: Biological Effects and Nutritional Essentiality 1989 Plenum Publishing Corporation New York, NY. .
30. Simopoulos, A. P., Kife, R. R., Martin, R. E. & Barlow, S. M. (1991) Health effects of 3 polyunsaturated fatty acids in seafoods. World Rev. Nutr. Diet. 66:1-592.
31. Galli, C., Simopoulos, A. P. & Tremoli, E. (1994) Effects of fatty acids and lipids in health and disease. World Rev. Nutr. Diet. 76:1-152.
32. Galli, C., Simopoulos, A. P. & Tremoli, E. (1994) Fatty acids and lipids: biological aspects. World Rev. Nutr. Diet. 75:1-198.[Medline]
33. Salem, N., Jr., Simopoulos, A. P., Galli, C., Lagarde, M. & Knapp, H. (1996) Proceedings of the 2nd Congress of ISSFAL on Fatty Acids and Lipids from Cell Biology to Human Disease. Lipids 31(suppl.):S1-S326.
34. Lagarde, M., Spector, A. A., Galli, C, Hamazaki, T. & Knapp, H. (1999) Proceedings of the 3rd Congress of ISSFAL on Fatty Acids and Lipids from Cell Biology to Human Disease. Lipids 34(suppl.):S1-S350.
35. Hamazaki, T. Okuyama, H. eds. Fatty Acids and Lipids—New Findings 88 Karger Basel, Switzerland. .
36. Simopoulos, A. P. & Salem, N., Jr (1986) Purslane: a terrestrial source of omega-3 fatty acids [letter]. N. Engl. J. Med. 315:833.[Medline]
37. Simopoulos, A. P., Norman, H. A., Gillaspy, J. E. & Duke, J. A. (1992) Common purslane: a source of omega-3 fatty acids and antioxidants. J. Am. Coll. Nutr. 11:374-382.[Abstract]
38. Simopoulos, A. P., Norman, H. A. & Gillaspy, J. E. (1995) Purslane in human nutrition and its potential for world agriculture. World Rev. Nutr. Diet. 77:7-74.
39. Simopoulos, A. P. & Salem, N., Jr (1989) (n-3) Fatty acids in eggs from range-fed Greek chickens. N. Engl. J. Med. 321:1412.[Medline]
40. Simopoulos, A. P. & Salem, N., Jr (1992) Egg yolk as a source of long-chain polyunsaturated fatty acids in infant feeding. Am. J. Clin. Nutr. 55:411-414.
41. Litin, L. & Sacks, F. (1993) Trans-fatty-acid content of common foods. N. Engl. J. Med. 329:1969-1970.
42. Sandker, G. W., Kromhout, D., Aravanis, C., Bloemberg, B. P., Mensink, R. P., Karalias, N. & Katan, M. B. (1993) Serum lipids in elderly men in Crete and The Netherlands. Eur. J. Clin. Nutr. 47:201-208.[Medline]
43. Renaud, S., Godsey, F., Dumont, E., Thevenon, C., Ortchanian, E. & Martin, J. L. (1986) Influence of long-term diet modification on platelet function and composition in Moselle farmers. Am. J. Clin. Nutr. 43:136-150.
44. Slater, T. F. & Block, G. (1991) Antioxidant vitamins and ß-carotene in disease prevention. Am. J. Clin. Nutr. 53(suppl.):189S-396S.[Medline]
45. Hertog, M.G.L., Hollman, P.C.H. & Katan, M. B. (1992) Content of potentially anticarcinogenic flavonoids of 28 vegetables and 9 fruits commonly consumed in The Netherlands. J. Agric. Food Chem. 40:2379-2383.
46. Mazur, W. M., Duke, J. A., Wahala, K., Rasku, S. & Adlercreutz, H. (1998) Isoflavonoids and lignans in legumes—nutritional and health aspects in humans. J. Nutr. Biochem. 9:193-200.
47. Joseph, J. A., Shukitt-Hale, B., Denisova, N. A., Bielinski, D., Martin, A., McEwen, J. J. & Bickford, P. C. (1999) Reversals of age-related declines in neuronal signal transduction, cognitive, and motor behavioral deficits with blueberry, spinach, or strawberry dietary supplementation. J. Neurosci. 19:8114-8121.
48. Weisburger, J. H. (1999) Mechanisms of action in antioxidants as exemplified in vegetables, tomatoes and tea. Food Chem. Toxicol. 37:943-948.[Medline]
49. Burr, M. L., Fehiliy, A. M., Gilbert, J. F., Rogers, S., Holliday, R. M., Sweetnam, P. M., Elwood, P. C. & Deadman, N. M. (1989) Effect of changes in fat, fish and fibre intakes on death and myocardial reinfarction. Diet and Reinfarction Trial (DART). Lancet ii:757-761.
50. GISSI-Prevenzione Investigators (1999) Dietary supplementation with n-3 polyunsaturated fatty acids and vitamin E after myocardial infarction. Results of the GISSI-Prevenzione trial. Lancet 354:447-455.[Medline]
51. Birch, E. E., Hoffman, D. R., Uauy, R., Birch, D. G. & Prestidge, C. (1998) Visual acuity and the essentiality of docosahexaenoic acid and arachidonic acid in the diet of term infants. Pediatr. Res. 44:201-209.[Medline]
52. Uauy, R., Hoffman, D., Birch, E., Birch, D., Jameson, D. & Tyson, J. (1994) Safety and efficacy of -3 fatty acids in the nutrition of very low birth weight infants. Soy oil and marine oil supplementation of formula. J. Pediatr. 124:612-620.[Medline]
53. Birch, E., Birch, D., Hoffman, D., Hale, L., Everett, M. & Uauy, R. (1993) Breast-feeding and optimal visual development. J. Pediatr. Ophthalmol. Strabismus 30:33-38.[Medline]
54. Leaf, A. & Weber, P. C. (1988) Cardiovascular effects of n-3 fatty acids. N. Engl. J. Med. 318:549-557.[Medline]
55. Simopoulos, A. P. (1997) -3 Fatty acids in the prevention-management of cardiovascular disease. Can. J. Physiol. Pharmacol. 75:234-239.[Medline]
56. Simopoulos, A. P. (1999) Essential fatty acids in health and chronic disease. Am. J. Clin. Nutr. 70(suppl.):560S-569S.
57. Simopoulos, A. P., Leaf, A. & Salem, N., Jr (1999) Essentiality of and recommended dietary intakes for omega-6 and omega-3 fatty acids. Ann. Nutr. Metab. 43:27-130.
58. Levi, F., La Vecchia, C., Lucchini, F. & Negri, E. (1995) Cancer mortality in Europe, 1990–1992. Eur. J. Cancer Prev. 4:389-417.[Medline]
59. Cowing, B. E. & Saker, K. E. (2001) Polyunsaturated fatty acids and epidermal growth factor receptor/mitogen-activated protein kinase signaling in mammary cancer. J. Nutr. 131:1125-1128.
60. Galli, C. & Butrum, R. (1991) Dietary 3 fatty acids and cancer: an overview. World Rev. Nutr. Diet. 66:446-461.[Medline]
61. Cave, W. T., Jr (1991) 3 Fatty acid diet effects on tumorigenesis in experimental animals. World Rev. Nutr. Diet. 66:462-476.[Medline]
62. Karmali, R. A. (1987) Fatty acids: inhibition. Am. J. Clin. Nutr. 45(suppl.):225-229.
63. Nielsen, N. H. & Hansen, J.P.H. (1980) Breast cancer in Greenland—-selected epidemiological, clinical and histological features. J. Cancer Res. Clin. Oncol. 98:287-299.[Medline]
64. Klein, V., Chajes, V., Germain, E., Schulgen, G., Pinault, M., Malvy, D., Lefranq, T., Fignon, A., Le Floch, O., L’huillery, C. & Bougnoux, P. (2000) Low alpha-linolenic acid content of adipose breast tissue is associated with an increased risk of breast cancer. Eur. J. Cancer 36:335-340.
65. Terry, P., Lichtenstein, P., Feychting, M., Ahlbom, A. & Wolk, A. (2001) Fatty fish consumption and risk of prostate cancer. Lancet 357:1764-1766.[Medline]
66. Kojima, M., Morisaki, T., Uchiyama, A., Doi, F., Mibu, R., Katano, M. & Tanaka, M. (2001) Association of enhanced cyclooxygenase-2 expression with possible local immunosuppression in human colorectal carcinomas. Ann. Surg. Oncol. 8:458-465.[Medline]
67. Chen, Z. Y. & Istfan, N. W. (2000) Docosahexaenoic acid is a potent inducer of apoptosis in HT-29 colon cancer cells. Prostaglandins Leukot. Essent. Fatty Acids 63:301-308.[Medline]
68. Diep, Q. N., Touyz, R. M. & Schiffrin, E. L. (2000) Docosahexaenoic acid, a peroxisome proliferator-activated receptor-alpha ligand, induces apoptosis in vascular smooth muscle cells by stimulation of p38 mitogen-activated protein kinase. Hypertension 36:851-858.
69. Xi, S., Pham, H. & Ziboh, W. A. (2000) 15-Hydroxyeicosatrienoic acid (15-HETrE) suppresses epidermal hyperproliferation via the modulation of nuclear transcription factor (AP-1) and apoptosis. Arch. Dermatol. Res. 292:397-403.[Medline]
70. Albino, A. P., Juan, G., Traganos, F., Reinhart, L., Connolly, J., Rose, D. P. & Darzynkiewicz, Z. (2000) Cell cycle arrest and apoptosis of melanoma cells by docosahexaenoic association with decreased pRb phosphorylation. Cancer Res 60:4139-4145.
71. Connolly, J. M., Gilhooly, E. M. & Rose, D. P. (1999) Effects of reduced dietary linoleic acid intake, alone or combined with algal source of docosahexaenoic acid, on MDA-MB-231 breast cancer growth and apoptosis in nude mice. Nutr. Cancer 35:44-49.[Medline]
72. Calviello, G., Palozza, P., Maggiano, N., Franceschelli, P., Di Nicuolo, F., Marcocci, M. E. & Bartoli, G. M. (1999) Effects of eicosapentaenoic and docosahexaenoic acids dietary supplementation on cell proliferation and apoptosis in rat colonic mucosa. Lipids 34(suppl.):S111.
73. Wigmore, S. J., Ross, J., Falconer, J. S., Plester, C. E., Tisdale, M. J., Carter, D. C. & Fearon, K. C. (1996) The effect of polyunsaturated fatty acids on the progress of cachexia in patients with pancreatic cancer. Nutrition 12(suppl. 1):27-30.
74. Gogos, C. A., Ginopoulos, P., Salsa, B., Apostolidou, E., Zoumbos, N. C. & Kalfarentzos, F. (1998) Dietary omega-3 polyunsaturated fatty acids plus vitamin E restore immunodeficiency and prolong survival for severely ill patients with generalized malignancy: a randomized control trial. Cancer 82:395-402.[Medline]
75. Clark, L. C., Combs, G. F., Jr, Turnbull, B. W., Slate, E. H., Chalker, D. K., Chow, J., Davis, L. S., Glover, R. A., Graham, G. F., Gross, E. G., Krongrad, A., Lesher, J. L., Jr, Park, H. K., Sanders, B. B., Jr, Smith, C. L. & Taylor, J. R. (1996) Effects of selenium supplementation for cancer prevention in patients with carcinoma of the skin: a randomized controlled trial. Nutritional Prevention of Cancer Study Group. J. Am. Med. Assoc. 276:1957-1963.
76. Yoshizawa, K., Willett, W. C., Morris, S. J., Stampfer, M. J., Spiegelman, D., Rimm, E. B. & Giovannucci, E. (1998) Study of prediagnostic selenium levels in toenails and the risk of advanced prostate cancer. J. Natl. Cancer Inst. 90:1219-1224.
77. Griffin, A. C. (1982) The chemoprevention role of selenium carcinogenesis. Arnott, M. S. van Eys, J. Wang, Y.-M. eds. Molecular Interrelations of Nutrition and Cancer 1982:401-408 Raven Press New York, NY. .
78. Arichi, H., Kimura, Y., Okuda, H., Baba, K., Kozawa, M. & Arichi, S. (1982) Effects of stilbene components of the roots of Polygonum cuspidatum Sieb. et Zucc. on lipid metabolism. Chem. Pharm. Bull. 30:1766-1770.
79. Kimura, Y., Okuda, H. & Arichi, S. (1985) Effects of stilbenes on arachidonate metabolism in leukocytes. Biochim. Biophys. Acta 834:275-278.[Medline]
80. Kimura, Y., Okuda, H. & Arichi, S. (1985) Effects of stilbene derivative on arachidonate metabolism in leukocytes. Biochim. Biophys. Acta 837:209-212.[Medline]
81. Kimura, Y., Okuda, H. & Kubo, M. (1995) Effects of stilbenes isolated from medicinal plants on arachidonate metabolism and degranulation in human polymorphonuclear leukocytes. J. Ethnopharmacol. 45:131-139.[Medline]
82. Jang, M., Cai, L., Udeani, G. O., Slowing, K. V., Thomas, C. F., Beecher, C.W.W., Fong, H.H.S., Farnsworth, N. R., Kinghorn, A. D., Mehta, R. G., Moon, R. C. & Pezzuto, J. M. (1997) Cancer chemopreventive activity of resveratrol, a natural product derived from grapes. Science (Washington DC) 275:218-220.
83. Ciolino, H. P., Daschner, P. J. & Yeh, G. C. (1998) Resveratrol inhibits transcription of CYP1A1 in vitro by preventing activation of the aryl hydrocarbon receptor. Cancer Res 58:5707-5712.
84. Ragione, F. D., Cucciolla, V., Borriello, A., Pietra, V. D., Racioppi, L., Soldati, G., Hanna, C., Galletti, P & Zappia, V. (1998) Resveratrol arrests the cell division cycle at S/G2 phase transition. Biochem. Biophys. Res. Commun. 250:5-58.[Medline]
85. Fontecave, M., Lepoivre, M., Elleingand, E., Gerez, C. & Guittelet, O. (1998) Resveratrol, a remarkable inhibitor of ribonucleotide reductase. FEBS Lett 421:277-279.[Medline]
86. Subbaranmaiah, K., Chung, W. J., Michaluart, P., Telang, N., Tanabe, T., Inoue, H., Jang, M., Pezzuto, J. M. & Dannenberg, A. J. (1998) Resveratrol inhibits cyclooxygenase-2 transcription and activity in phorbol ester-treated human mammary epithelial cell. J. Biol. Chem. 273:21875-21882.
87. Sun, N. J., Woo, S. H., Cassady, J. M. & Snapka, R. M. (1998) DNA polymerase and topoisomerase II inhibitors from Psoralea corylifolia. J. Nat. Prod. 61:362-366.[Medline]
88. Clement, M.-V., Hirpara, J. L., Chawdhury, H.-H. & Pervaiz, S. (1998) Chemopreventive agent resveratrol, a natural product derived from grapes, triggers CD95 signaling-dependent apoptosis in human tumor cells. Blood 92:996-1002.
89. Carbo, N., Costelli, P., Baccino, F. M., Lopez-Soriano, F. J. & Argiles, J. M. (1999) Resveratrol, a natural product present in wine, decreases tumor growth in rat tumor model. Biochem. Biophys. Res. Commun. 254:739-743.[Medline]
90. Kimura, Y. & Okuda, H. (2001) Resveratrol isolated from Polygonum cuspidatum root prevents tumor growth and metastasis to lung and tumor-induced neovascularization in Lewis lung carcinoma-bearing mice. J. Nutr. 131:1844-1849.
91. Jones, D. P., Hagen, T. M., Weber, R., Wierzbicka, G. T. & Bonkovsky, H. L. (1989) Oral administration of glutathione (GSH) increases plasma GSH concentrations in humans. FASEB J 3:A1250(abs).
92. Jones, D. P., Coates, R. J., Flagg, E. W., Eley, J. W., Block, G., Greenberg, R. S., Gunter, E. W. & Jackson, B. (1992) Glutathione in foods listed in the National Cancer Institute’s Health Habits and History Food Frequency Questionnaire. Nutr. Cancer 17:57-75.[Medline]
93. Block, G., Dresser, C. M., Hartman, A. M. & Carroll, M. D. (1985) Nutrient sources in the American diet: quantitative data from the NHANES II survey I. Vitamins and minerals. Am. J. Epidemiol. 122:13-26.
94. Block, G., Dresser, C. M., Hartman, A. M. & Carroll, M. D. (1985) Nutrient sources in the American diet: quantitative data from the NHANES II survey II. Macronutrients and fats. Am. J. Epidemiol 122:27-40.
95. Mannervick, B., Carlberg, I. & Larson, K. (1989) Glutathione: general review of mechanism of action. Glutathione 1989 Chemical Biochemical and Medical Aspects (Dolphin, D., Avramovic, O. & Pulson, R., eds.), Part A, pp. 475–516. Wiley, New York, NY. .
96. Wattenberg, L. W. (1985) Perspectives in cancer research. Chemoprevention of cancer. . Cancer Res. 45:1-8.
97. Frei, B., England, L. & Ames, B. N. (1989) Ascorbate is an outstanding antioxidant in human blood plasma. Proc. Natl. Acad. Sci. U.S.A. 86:6377-6381.
98. Bendich, A. (1985) Antioxidant micronutrients in immune responses. Bendich, A. Chandra, R. K. eds. Micronutrients and Immune Functions 587:169-180 New York Academy of Sciences New York, NY. .
99. Frei, B., Stocker, R. & Ames, B. N. (1988) Antioxidant defenses and lipid peroxidation in human blood. Proc. Natl. Acad. Sci. U.S.A. 85:9748-9752.
100. Oleinick, N. L., Xue, L., Friedman, L. R., Donahue, L. L. & Biaglow, J. E. (1988) Inhibition of radiation-induced DNA-protein cross-link repair by glutathione depletion with L-buthionine sulfoximine. NCI Monogr 6:225-229.
101. Fuchs, J. A. (1989) Glutaredoxin. Glutathione 1989 Chemical Biochemical and Medical Aspects (Dolphin, D., Avramovic, O. & Poulson, R., eds.), Part B, pp. 551–570. Wiley, New York, NY. .
102. Furukawa, T., Meydani, S. N. & Blumberg, J. B. (1987) Reversal of age-associated decline in immune responsiveness by dietary glutathione supplementation in mice. Mech. Ageing Dev. 38:107-117.[Medline]
103. Buhl, R., Jaffe, H. A., Holroyd, K. J., Wells, F. B., Mastrangeli, A., Saltini, C., Cantin, A. M. & Crystal, R.G. (1989) Systemic glutathione deficiency in symptom-free HIV-seropositive individuals. Lancet ii:1294-1298.
104. Flagg, E. W., Coates, R. J., Jones, D. P., Eley, J. W., Gunter, E.W., Jackson, B. & Greenberg, R. S. (1993) Plasma total glutathione in humans and its association with demographic and health-related factors. Br. J. Nutr. 70:797-808.[Medline]
105. McCay, P. B. (1985) Vitamin E: interactions with free radicals and ascorbate. Annu. Rev. Nutr. 5:323-340.[Medline]
106. Renneberg, H. (1982) Glutathione metabolism and possible biological roles in the higher plant. Phytochemistry 21:2771-2781.
107. Renneberg, H. (1987) Aspects of glutathione function and metabolism in plants. Von Wettstein, D. Chua, N. H. eds. Plant Molecular Biology 1987:279-292 Plenum Press New York, NY. .
108. Hatzios, K. K. & Bormann, J. F. (1989) Proceedings 1989 Annual Symposium South ASPP: glutathione synthesis and function in higher plants. Physiol. Plant 77:447-471.
109. Koike, S. & Patterson, B. D. (1988) Diurnal variation of glutathione levels in tomato seedlings. Hortic. Sci. 23:713-714.
110. Schupp, R. & Rennenberg, H. (1988) Diurnal changes in the glutathione content of spruce needles (Picea abies L.). Plant Sci. 57:113-117.
111. Earnshaw, B. A. & Johnson, M.A. (1987) Control of wild carrot somatic embryo development by antioxidants. Plant Physiol 85:273-276.
112. De Kok, L. J., De Kan, P.J.L., Tanczos, O. G. & Kuiper, P.J.C. (1981) Sulphate-induced accumulation of glutathione and frost-tolerance of spinach leaf tissue. Physiol. Plant 53:435-438.
113. Wise, R. R. & Naylor, A. W. (1987) Chilling-enhanced photooxidation. The peroxidative destruction of lipids during chilling injury to photosynthesis and ultrastructure. Plant Physiol. 83:272-277.
114. Simopoulos, A. P. (1996) The Mediterranean Food Guide. Greek column rather than an Egyptian pyramid. Nutr. Today 30:54-61.
This article has been cited by other articles:
|
|
 |
|
  D. Kiefer, J. Pitluk, and K. Klunk An Overview of CAM: Components and Clinical Uses Nutr Clin Pract, October 1, 2009; 24(5): 549 - 559. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Zhang, J. Zhang, Z. Ungvari, and C. Zhang Resveratrol Improves Endothelial Function: Role of TNF{alpha} and Vascular Oxidative Stress Arterioscler Thromb Vasc Biol, August 1, 2009; 29(8): 1164 - 1171. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Wertz Essential fatty acids and dietary stress Toxicology and Industrial Health, May 1, 2009; 25(4-5): 279 - 283. [Abstract] [PDF]
|
|
|
|
 |
|
 M. D. Kontogianni, N. Vidra, A.-E. Farmaki, S. Koinaki, K. Belogianni, S. Sofrona, F. Magkanari, and M. Yannakoulia Adherence Rates to the Mediterranean Diet Are Low in a Representative Sample of Greek Children and Adolescents J. Nutr., October 1, 2008; 138(10): 1951 - 1956. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Munshi, L. H. Ni, and M. S. Tiwana Complementary and Alternative Medicine in Present Day Oncology Care: Promises and Pitfalls Jpn. J. Clin. Oncol., August 5, 2008; (2008) hyn066v1. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F.N. Salta, A. Mylona, A. Chiou, G. Boskou, and N.K. Andrikopoulos Oxidative Stability of Edible Vegetable Oils Enriched in Polyphenols with Olive Leaf Extract Food Science and Technology International, December 1, 2007; 13(6): 413 - 421. [Abstract] [PDF]
|
|
|
|
|
|
M. E. Juan, U. Wenzel, V. Ruiz-Gutierrez, H. Daniel, and J. M. Planas Olive Fruit Extracts Inhibit Proliferation and Induce Apoptosis in HT-29 Human Colon Cancer Cells J. Nutr., October 1, 2006; 136(10): 2553 - 2557. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Souzeau, S. Belanger, S. Picard, and C. F. Deschepper Dietary isoflavones during pregnancy and lactation provide cardioprotection to offspring rats in adulthood Am J Physiol Heart Circ Physiol, August 1, 2005; 289(2): H715 - H721. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. C Larsson, M. Kumlin, M. Ingelman-Sundberg, and A. Wolk Dietary long-chain n-3 fatty acids for the prevention of cancer: a review of potential mechanisms Am. J. Clinical Nutrition, June 1, 2004; 79(6): 935 - 945. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. B. Izevbigie, J. L. Bryant, and A. Walker A Novel Natural Inhibitor of Extracellular Signal-Regulated Kinases and Human Breast Cancer Cell Growth Experimental Biology and Medicine, February 1, 2004; 229(2): 163 - 169. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. A. Norman, R. R. Butrum, E. Feldman, D. Heber, D. Nixon, M. F. Picciano, R. Rivlin, A. Simopoulos, M. J. Wargovich, E. K. Weisburger, et al. The Role of Dietary Supplements during Cancer Therapy J. Nutr., November 1, 2003; 133(11): 3794S - 3799. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. H. Weisburger Lycopene and Tomato Products in Health Promotion Experimental Biology and Medicine, November 1, 2002; 227(10): 924 - 927. [Abstract] [Full Text] [PDF]
|
|
| |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
