QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (Publish Ahead of Print[PDF]) Online Supplemental Material All Versions of this Article: 139/12/2301    most recent jn.109.109900v1 Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Google Scholar Articles by Mattei, J. Articles by Ordovas, J. M. PubMed PubMed Citation Articles by Mattei, J. Articles by Ordovas, J. M.

---

Genomics, Proteomics, and Metabolomics

Apolipoprotein A5 Polymorphisms Interact with Total Dietary Fat Intake in Association with Markers of Metabolic Syndrome in Puerto Rican Older Adults^1,2,3

⁴ Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111 ⁵ Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA 02111 ⁶ Department of Biostatistics, School of Public Health, Boston University, Boston, MA 02118

APOA5 -1131T > C and S19W single nucleotide polymorphisms (SNP) have been consistently associated with plasma lipid concentration and metabolic syndrome (MetS), alone and in modulation by dietary factors. Puerto Ricans have a high prevalence of metabolic conditions and high minor allele frequency for these SNP, suggesting a possible role in disease for this population. We aimed to determine the association of APOA5 -1131T > C and S19W with plasma lipids and markers of MetS, alone and in interaction with total fat intake, as a percent of total energy intake, in Puerto Ricans. Anthropometric and demographic data, FFQ, and blood samples were collected at baseline from participants in the Boston Puerto Rican Health Study (n = 802, 45–75 y). APOA5 S19W was associated with plasma HDL cholesterol (HDL-C) (P = 0.044); minor allele carriers had lower HDL-C [1.12 ± 0.03 (mean ± SE)] than those with the common variant (1.18 ± 0.01 mmol/L), even after adjustment for plasma triglycerides (TG) (P = 0.012). Neither polymorphism was associated with TG or other lipids. Interaction of the -1131T > C SNP with total fat energy intake was observed for plasma TG (P = 0.032) and total cholesterol (P = 0.034). APOA5 S19W interacted with total fat intake in association with systolic (P = 0.002) and diastolic (P = 0.007) blood pressure. Neither SNP was associated with MetS in the overall analysis or after stratifying by total energy intake as fat. In conclusion, Puerto Ricans present a distinctive lipid profile in association with APOA5 polymorphisms. Dietary fat intake seems to modulate these associations. The results contribute to the understanding of health disparities in this population.

^* To whom correspondence should be addressed. E-mail: jose.ordovas{at}tufts.edu.

Manuscript received 7 May 2009. Initial review completed 3 June 2009. Revision accepted 1 September 2009.