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Journal of Nutrition Vol. 99 No. 4 December 1969, pp. 519-530
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A Histochemical Study of Enzyme Changes and Ultrastructure of the Jejunal Mucosa in Protein-depleted Rats1

Badri N. Tandon2, Paul M. Newberne and Vernon R. Young

Department of Nutrition and Food Science, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139

Histochemical estimation of selected brushborder, mitochondrial, lysosomal and microsomal enzymes, and observations on the ultrastructure were made on the jejunal mucosa of young rats fed a low protein diet for 10 weeks. The ultrastructure of the microvilli was not altered nor were there changes in the brushborder enzymes examined. Acid phosphatase and succinic dehydrogenase were significantly reduced, although the mitochondria appeared normal in fine structure. Glucose-6 phosphatase activity was unchanged, and this correlated with the maintenance of the rough endoplasmic reticulum. The significance of these observations is discussed in relation to malabsorption which has been observed in clinical protein-calorie malnutrition.

1 Financial aid provided in part by Grant no. 386 from the Nutrition Foundation, Inc., New York, and in part by Contract no. DA-49-193-MD-2560 with the U.S. Army Medical Research and Development Command. This is publication no. 1496 from the Department of Nutrition and Food Science, Massachusetts Institute of Technology.

2 Supported by a fellowship from the Rockefeller Foundation. Present Address: Department of Medicine, All India Institute of Medical Sciences, Medical Enclave, New Delhi 16, India.

Manuscript received 1 July 1969.




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