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Evaluation of Bone Calcium Accretion Rate as a Function of Age in Beagle Dogs¹

Department of Physical Biology, New York State Veterinary College, Cornell University, Ithaca, New York 14850

In an attempt to determine normal bone growth rate patterns in beagle dogs, bone calcium accretion studies were performed on a group of six animals periodically from age 6 weeks to age 13 months. Accretion rates (A values) were determined by a whole-body counting technique using ⁴⁷Ca as the tracer. On the basis of the entire skeleton, A values rose from about 1.8 g/day at 6 weeks of age to a maximum of about 3.3 g/day at age 2.5 months. From age 2.5 to 5.0 months, A values remained at a level of 2.8 to 3.0 g/day after which they gradually fell to a low of 0.3 g/day at 13 months of age. Accretion rates for the whole skeleton appeared to follow the growth rate data for beagle dogs. On the basis of unit bone mass, A values decreased from a maximum of 13.80 mg Ca/gram bone per day at 6 weeks to a low of 0.34 mg Ca/g bone per day at age 13 months. The exchangeable calcium-pool size changed roughly in proportion to the A values. The 3-week retention of isotope was greatest at the earliest ages, and decreased with age thereafter.

Manuscript received 22 July 1969.