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Tissue Lactic Dehydrogenase, Glutamic-oxalacetic Transaminase, and Peroxidase Changes of Selenium-deficient Myopathic Lambs^1,2,

Departments of Agricultural Chemistry, Veterinary Medicine and Animal Science, Oregon State University, Corvallis, Oregon

The concentrations of lactic dehydrogenase (LDH), glutamic-oxalacetic transaminase (GOT), and peroxidase were determined in heart, liver, kidney, spleen, and skeletal muscles (semitendinosus and longissimus dorsi) of normal and selenium-deficient myopathic lambs. There were no differences in the concentrations of these enzymes in the heart, liver (except LDH), kidney, and spleen of normal and myopathic lambs, but there was a significant reduction in the concentration of these enzymes in the skeletal muscles. Severely affected myopathic lambs had a significantly lower LDH in the livers. The concentration of LDH, GOT, and peroxidase in the skeletal muscles was correlated with the severity of damage to these muscles. Two of the lysosomal enzymes, aryl sulfatase and ß-glucuronidase, were significantly higher in skeletal muscles of myopathic lambs. There were no differences in the concentrations of LDH, peroxidase, or aryl sulfatase in hearts from lambs with heart lesions as compared to those without these lesions.

² Supported in part by Public Health Service Research grant no. NB 07413-01 from the National Institute of Neurological Diseases and Blindness.

Manuscript received 7 May 1969.