Journal of Nutrition

Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
QUICK SEARCH:   [advanced]


     

Journal of Nutrition Vol. 99 No. 3 November 1969, pp. 261-266
Copyright © 1969 by American Society for Nutrition
This Article
Right arrow Full Text (PDF)
Right arrow Purchase Article
Right arrow View Shopping Cart
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Ginter, E.
Right arrow Articles by Simko, V.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Ginter, E.
Right arrow Articles by Simko, V.

The Influence of Chronic Vitamin C Deficiency on Fatty Acid Composition of Blood Serum, Liver Triglycerides and Cholesterol Esters in Guinea Pigs

E. Ginter, R. Ondreicka, P. Bobek and V. Simko

Institute of Human Nutrition Research, Bratislava, Czechoslovakia

Chronic hypovitaminosis C (2-week scorbutogenic regime followed by administration of maintenance dose of 0.5 mg ascorbic acid for 24 hours) in guinea pigs produced hypercholesterolemia and an increased accumulation of cholesterol in liver. Deficiency of ascorbic acid increased significantly the content of saturated fatty acids (up to chain length C16) and decreased content of mono- and polyunsaturated fatty acids in cholesterol esters of liver. Similar changes were observed after administration of the same diet supplemented with 0.25% of cholesterol to guinea pigs saturated with vitamin C. In blood serum of vitamin C-deficient guinea pigs, the cholesterol esters contain an increased amount of linoleic acid and a decreased amount of palmitic and oleic acids. The spectrum of fatty acids in triglycerides of blood serum and liver was not significantly affected by hypovitaminosis C. It is surmised that the primary cause of the observed changes is the disturbance of cholesterol metabolism, produced by chronic vitamin C deficiency.

Manuscript received 14 April 1969.


This article has been cited by other articles:


Home page
 ScienceHome page
E. Ginter
Cholesterol: Vitamin C Controls Its Transformation to Bile Acids
Science, February 16, 1973; 179(4074): 702 - 704.
[Abstract] [PDF]


Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]