Journal of Nutrition Animal Diets/Enrichment Products...

Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
QUICK SEARCH:   [advanced]


     

Journal of Nutrition Vol. 99 No. 1 September 1969, pp. 51-57
Copyright
This Article
Right arrow Full Text (PDF)
Right arrow Purchase Article
Right arrow View Shopping Cart
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Jacob, M.
Right arrow Articles by Forbes, R. M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Jacob, M.
Right arrow Articles by Forbes, R. M.

Effects of Magnesium Deficiency, Dietary Sulfate and Thyroxine Treatment on Kidney Calcification and Tissue Protein-bound Carbohydrate in the Rat1

Mary Jacob2 and R. M. Forbes

Nutritional Biochemistry Division, Animal Science Department, University of Illinois, Urbana, Illinois

Three experiments were conducted to investigate relationships between calcium accumulation in the kidney and changes in ground substrance of the magnesium-deficient young male albino rat. It was found that a modest dietary sulfate deficiency did not prevent kidney calcification, nor did it prevent the lowered liver protein-bound hexose/hexosamine ratio of magnesium-deficient animals. Dietary L-thyroxine (L-T4) prevented kidney calcification, lowered total serum protein and the percentage of glycoprotein in the serum protein. Magnesium deficiency lowered total protein in serum but not glycoprotein content of the serum protein. Retention of 35S in serum and bone 48 hours after dosing was decreased by magnesium deficiency and especially by L-T4 treatment. Kidney 35S retention 48 hours after a single dose was greater in animals fed a magnesium-deficient diet for 14 days than for 4 days except in L-T4 treated animals. Kidney calcification and 35S retention were not affected by intraperitoneal dosage with D-T4. On the basis of these experiments it appears that the initial stages of kidney calcification arising from magnesium deficiency do not involve changes in ground substance, although such changes may contribute to the later, more extensive calcification.

1 This paper includes portions of a thesis submitted by Mary Jacob to the Graduate College, University of Illinois at Urbana-Champaign in partial fulfillment of the requirements for the Doctoral degree in Nutritional Sciences.

2 Present address: School of Public Health, University of California, Los Angeles.

Manuscript received 7 April 1969.




Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]