QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Konlande, J. E. Articles by Fisher, H. Search for Related Content PubMed PubMed Citation Articles by Konlande, J. E. Articles by Fisher, H.

Evidence for a Nonabsorptive Antihypercholesterolemic Action of Phytosterols in the Chicken¹

Department of Nutrition, Rutgers University, New Brunswick, New Jersey

Soy sterols were administered orally (1% of diet) and subcutaneously (20 mg/day) to chicks with hypercholesterolemia induced by feeding a low protein, cholesterol-containing diet (8% protein, 5% medium-chain triglycerides (MCT), and 0.5% cholesterol). Sterol levels and patterns in plasma, tissues, and excreta were determined by spectrophotometric and gas-liquid chromatographic analysis. Strong evidence for a nonabsorptive antihypercholesterolemic action of soy sterols included: similar liver cholesterol reductions for both oral and subcutaneous soy sterol administration, and reduction by subcutaneous soy sterol injection of endogenous hypercholesterolemia due to ova resorption induced by feeding 0.04% Nicarbazin to laying hens. Estimation of absorptive effects from intestinal wall concentrations of cholesterol, and subtraction of these effects from total antihypercholesterolemic effects, indicated approximately equal absorptive and nonabsorptive activity from oral soy sterols and a predominantly nonabsorptive effect of subcutaneously administered soy sterols. A comparison of the oral administration of 1% soy sterols and 1% wheat germ sterols to chicks given a hypercholesterolemic diet (25% whole egg powder) resulted in a greater antihyper-cholesterolemic response from soy sterols which contain more campesterol (36%) than from wheat germ sterols (25% campesterol). Campesterol appears to be the major active component of soy and wheat sterols in relation to their antihypercholesterolemic activity.

² NDEA Title IV Fellow.

Manuscript received 27 February 1969.