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Journal of Nutrition Vol. 98 No. 4 August 1969, pp. 404-410
Copyright © 1969 by American Society for Nutrition
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Artificial Feeding of Infant Rats by Continuous Gastric Infusion1

Michael Messer2, Evelyn B. Thoman, Alberto Galofre Terrasa and Peter R. Dallman3

Department of Pediatrics and Human Development, and the Department of Psychiatry, Stanford University School of Medicine, Stanford, California

A technique for the artificial feeding of infant rats by continuous gastric infusion is described. Using an infusion pump, a milk diet is continuously conveyed to the stomach of the animal via a gastric cannula which has been surgically implanted by gastrostomy shortly after birth. The method is designed to raise eight rats from birth to the age of weaning. Normal growth rates can be approximated. Because the technique is semiautomatic it has the advantage over other methods of artificial feeding in that it avoids the danger of trauma that accompanies repeated passage of oral-gastric feeding tubes. In addition, it eliminates the need for attendance during the night and can be readily handled by a single investigator.

1 Supported in part by Public Health Service Research Grants nos. HE 10050, HD 02147, and HD 00049, and a grant from the National Foundation — March of Dimes.

2 Present address: Department of Biochemistry, University of Sydney, N.S.W. 20006, Australia.

3 Recipient of Public Health Service Research Career Program Award no. HE 07184. Present address: Department of Pediatrics, San Francisco Medical Center, San Francisco, California 94122.

Manuscript received 13 March 1969.


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