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Some Selenium Responses in the Rat not Related to Vitamin E^1,2,3,

Department of Agricultural Chemistry, Oregon State University, Corvallis, Oregon

Rats fed a low selenium ration containing Torula yeast with adequate vitamin E grew and reproduced normally. Their offspring were almost hairless, grew more slowly and failed to reproduce. Supplemental dl-methionine, sodium sulfate, or increased dosage of vitamins was without effect. Supplementing with 0.1 ppm selenium as sodium selenite restored haircoat, growth, and reproductive capabilities. Some usual biochemical tests for selenium or vitamin E deficiency status, or both, were inconclusive when compared with rats fed normal rations. Rats fed low selenium corn protein also had sparse hair and poor growth in the second generation. A low selenium ration from ewe muscle, however, supported rats for three generations without any abnormalities.

² Supported in part by Public Health Research Grant no. HE 09228 from the National Institutes of Health.

³ This report constitutes a portion of a thesis submitted by Kim E. M. McCoy in partial fulfillment of the requirements for the Ph.D. degree.

Manuscript received 14 March 1969.

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