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Impairment of Gastrointestinal Processing of Fat and Protein by Ethanol in Rats¹

Research and Radioisotope Services, Wood Veterans Administration Hospital and Departments of Pharmacology and Medicine, Marquette School of Medicine, Milwaukee, Wisconsin

Ethanol, administered simultaneously with corn oil and trace amounts of ¹³¹I triolein to fasting rats, temporarily delayed the removal of the radioactivity from the gastrointestinal tract. This interference with fat absorption was dose-dependent; no significant delaying effect was seen with 2 g ethanol/kg body weight, whereas a retardation of absorption was observed with doses of 3 g or more of ethanol per kilogram body weight. The removal of ¹³¹I triolein or ¹³¹I oleic acid from the gastrointestinal tract was inhibited to about the same degree, indicating that blocking of intestinal lipase activity by ethanol was not an important factor in this interference. Administration of alcohol also led to retention of a protein meal in the stomach.

Manuscript received 3 March 1969.

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