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Journal of Nutrition Vol. 98 No. 3 July 1969, pp. 312-318
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Dietary Fat and the Inhibition of Hepatic Lipogenesis in the Mouse1

John R. Sabine2, Hope McGrath3 and S. Abraham3

Departments of Physiology-Anatomy and Nutritional Sciences, University of California, Berkeley, California

We have examined the effects of dietary fat upon lipogenesis from 1-14C-acetate by slices of mouse liver, under two sets of conditions: a) a high fat diet (15% corn oil) was fed for 1 to 5 days, following zero, 1 and 2 days of fasting; and b) corn oil, safflower oil, coconut oil, tricaprylin, tripalmitin, triolein, oleic acid and mineral oil (all at 10% of the diet) were fed for 3 days, with no prior fasting. Of the high fat diets only those high in linoleic acid suppressed fatty acid synthesis. Corn oil reduced fatty acid synthesis in nonfasted mice, and suppressed the usual "adaptive hyperlipogenesis" found after fasting and refeeding. From this work, and that of others, it is now clear that any alteration in hepatic lipogenesis induced by the inclusion of fat in the diet will depend not only on the fatty acid composition of the fat, but also on the level in the diet, the length of time it is fed, the animal species and age examined, and on whether the studies are conducted in vivo or in vitro.

1 Supported by the American Cancer Society, by the Cancer Research Fund of the University of California, and by the National Institutes of Health through an Institutional Grant to the University of California, Berkeley. These studies were partly carried out while the senior author (John R. Sabine) held a Research Fellowship from the Damon Runyon Memorial Fund for Cancer Research, Inc.

2 Present address: Department of Animal Physiology, Waite Agricultural Research Institute, University of Adelaide, Glen Osmond, 5064, Australia.

3 Present address: Bruce Lyon Memorial Research Laboratory, Children's Hospital Medical Center, Oakland, California.

Manuscript received 27 December 1968.




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