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Bile Salt Enhancement of Riboflavin and Flavin Mononucleotide Absorption in Man¹

Department of Pharmaceutics, School of Pharmacy, State University of New York at Buffalo, Buffalo, New York

The gastrointestinal absorption of riboflavin and flavin mononucleotide (FMN) was determined under control conditions and after oral administration of 600 mg sodium deoxycholate. When the bile salt is given prior to a 30-mg dose of riboflavin there is a 50 to 80% increase in total urinary recovery of apparent riboflavin. A similar, but less marked, enhancement is observed when the same dose of FMN is given with sodium deoxycholate. Urinary excretion data also suggest an unusually prolonged absorption of riboflavin in the presence of the bile salt. The possibility exists that the bile salt enhancement of riboflavin and FMN absorption may be due to changes in gastrointestinal motility or changes in the permeability of the gastrointestinal membranes to the transport of the vitamins, or both. Other possibilities are also explored.

² Fellow of the American Foundation for Pharmaceutical Education, 1968–1969.

³ Fellow of the American Foundation for Pharmaceutical Education, and Albert H. Diebold Memorial Fellow, 1968–1969.

Manuscript received 7 March 1969.