QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Spierto, F. Articles by Parker, H. E. Search for Related Content PubMed PubMed Citation Articles by Spierto, F. Articles by Parker, H. E.

Effect of Dietary Magnesium and Fluoride on Bone Mineralization in Young Chicks^1,2,3,

Departments of Biochemistry and Animal Science, Purdue University, Lafayette, Indiana

Tracer techniques were used to examine the reduced bone mineralization observed in young chicks fed diets elevated in both magnesium (4500 ppm) and fluoride (800 ppm). The distribution of ⁴⁵Ca 1 hour after injection of the isotope into a ligated intestinal segment was examined in 2-day-old chicks fed control and high magnesium plus high fluoride diets. Although no differences in intestinal absorption were observed, decreased femur uptake and increased plasma levels of ⁴⁵Ca were found in the chicks fed the high magnesium plus high fluoride diets. At an early age (2 to 6 days) chicks fed the high magnesium plus high fluoride diets incorporated less ⁴⁵Ca and ³²P into their femurs 4 hours after intraperitoneal injection when compared with chicks maintained on control, high fluoride or high magnesium diets. As a result of the reduced femur ⁴⁵Ca incorporation, plasma ⁴⁵Ca levels were elevated in the high magnesium plus high fluoride group. At later ages (8 to 10 days) incorporation of injected ³²P into femurs was not affected by dietary treatment, but ⁴⁵Ca incorporation was elevated in the high magnesium plus high fluoride group. Analysis of plasma and soft tissues for calcium revealed no treatment differences at 4 days, but ⁴⁵Ca levels in plasma 4 hours after intraperitoneal injection were elevated above control values at every age studied. Results of in vitro studies have suggested that bone from chicks in the magnesium plus fluoride group incorporate less ⁴⁵Ca and ³²P than bones from chicks in the other groups when incubated in plasma of chicks from the same treatment.

² Some of these data were presented at the 52nd Annual Meeting of the Federation of American Societies for Experimental Biology, Atlantic City, New Jersey, 1968, Federation Proc., 27: 312 (abstract).

³ Reprint requests should be sent to H. E. Parker, Biochemistry Department, Purdue University, Lafayette 47907.

⁴ Present address: Veterans Administration Hospital, 4801 Linwood Boulevard, Kansas City, Missouri.

Manuscript received 10 February 1969.