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Departments of Biochemistry and Internal Medicine, University of Chile, Santiago, Chile
The effect of ethanol on the absorption of L-methionine was studied in the human small intestine. It was shown that 2% ethanol significantly (P < 0.01) inhibited the absorption of this amino acid by 55%. A 40-g dose of alcohol was given orally to human volunteers as 10 and 20% solutions. Ethanol in the intestinal fluid reached concentrations of 2.5 to 3% and was maintained above 1% for 30 to 60 minutes. The possible significance of these findings is discussed in relation to the nutritional deficiencies that occur in chronic alcoholism in humans.
Manuscript received 21 January 1969.
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