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Journal of Nutrition Vol. 98 No. 2 June 1969, pp. 222-224
Copyright © 1969 by American Society for Nutrition
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Alcohol and Amino Acid Transport in the Human Small Intestine1

Y. Israel, J. E. Valenzuela, I. Salazar and G. Ugarte

Departments of Biochemistry and Internal Medicine, University of Chile, Santiago, Chile

The effect of ethanol on the absorption of L-methionine was studied in the human small intestine. It was shown that 2% ethanol significantly (P < 0.01) inhibited the absorption of this amino acid by 55%. A 40-g dose of alcohol was given orally to human volunteers as 10 and 20% solutions. Ethanol in the intestinal fluid reached concentrations of 2.5 to 3% and was maintained above 1% for 30 to 60 minutes. The possible significance of these findings is discussed in relation to the nutritional deficiencies that occur in chronic alcoholism in humans.


1 Supported by grants from the National Institutes of Health (USA); the Foundation's Fund for Research in Psychiatry (USA); the Alcoholism and Drug Addiction Research Foundation of Ontario, Canada; and the Foundation for Overseas Research Grants and Education (USA).

Manuscript received 21 January 1969.


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E. A. Carter, G. D. Drummey, and K. J. Isselbacher
Ethanol Stimulates Triglyceride Synthesis by the Intestine
Science, December 17, 1971; 174(4015): 1245 - 1247.
[Abstract] [PDF]




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