Journal of Nutrition

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Journal of Nutrition Vol. 98 No. 2 June 1969, pp. 181-187
Copyright © 1969 by American Society for Nutrition
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Preconception Irradiation of Dam and Composition of Offspring1

E. W. Hahn2 and F. W. Heggeness

Departments of Radiation Biology and Biophysics, and Physiology, University of Rochester School of Medicine and Dentistry, Rochester, New York

Whole-body X-irradiation of the female rat alters the ovulation response at next estrus. Number of ova shed can be predictably varied from 10 to 35 depending upon the dose and time in the estrous cycle it is administered. If bred, pregnancy is uneventful but litter size ranges from 2 to 18 pups, depending upon dose of radiation. The purpose of these experiments was to examine the effect of preconceptional irradiation and the number of pups per litter on the growth of the offspring. Fat content of newborn pups was not influenced by litter size or preconception irradiation. Total body nitrogen was 80% of control value in offspring of mothers given over 300 r with a maximal effect seen at 400 r. Nitrogen content was not related to litter size. Additional young were cross-fostered to unirradiated dams and then fed ad libitum. At 100 days nitrogen content of animals born of mothers administered up to 400 r was not different from control value, but was decreased to 90% of control value in offspring of females receiving 600 r. Growth potential appeared to be slightly but permanently modified by 600 r of preconceptional radiation.

1 Supported in part by National Institutes of Health Grant no. HD00009 and a contract with the U. S. Atomic Commission at the University of Rochester Atomic Energy Project. This report has been assigned no. UR 49-1027. The work was carried out during the tenure of F. W. Heggeness under Career Development Award no. 5K 3HD14907 from the Public Health Service.

2 Present address: Department of Radiology, University of Minnesota Medical School, Minneapolis, Minnesota 55455.

Manuscript received 24 January 1969.




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