QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Thierry, M. J. Articles by Suttie, J. W. Search for Related Content PubMed PubMed Citation Articles by Thierry, M. J. Articles by Suttie, J. W.

Distribution and Metabolism of Menadiol Diphosphate in the Rat¹

Department of Biochemistry, University of Wisconsin, Madison, Wisconsin

Physiological doses of radioactive menadiol diphosphate, an active water-soluble form of vitamin K, were administered by intraperitoneal injection to vitamin K-deficient male rats. The compound was not concentrated by any tissue but was distributed throughout all body organs in a manner which was not influenced by the vitamin K status of the animal. Seventeen hours after an intraperitoneal injection of the radioactive vitamin about 50% of the activity had been excreted, mainly in the urine. There was a general association of the injected compound or its metabolites with the membranous fractions of the cell. The data also indicate that there was a rapid conversion of this water-soluble compound to more lipophilic forms of the vitamin.

² Public Health Service Predoctoral fellow F-1 GM-35,372.

Manuscript received 30 October 1968.