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Influence of Ethionine on Choline-deficiency Fatty Liver¹

Department of Pathology, University of Pittsburgh, School of Medicine, Pittsburgh, Pennsylvania

Rats fed ad libitum a choline-deficient diet containing 0.25 or 0.5% ethionine for 7 to 21 days did not develop a choline-deficiency fatty liver. Likewise, rats force-fed a controlled intake of choline-deficient diet either supplemented with ethionine or receiving ethionine intraperitoneally for 3 days did not develop fatty liver. Rats force-fed the choline-supplemented or choline-deficient diet containing ethionine developed a small increase in liver lipid after 1 day, particularly if prefasted for 1 day, which diminished after 2 or 3 days. After induction of choline-deficiency fatty liver, the addition of ethionine to the deficient diet slowly decreased the lipid accumulation. The addition of methionine to the choline-deficient, ethionine-supplemented diet partially counteracted the inhibitory effect of ethionine on choline-deficiency fatty liver. Thus, ethionine, a compound which itself induces fatty liver when administered to fasted animals, is capable of inhibiting the induction of fatty liver due to choline deficiency.

Manuscript received 11 October 1968.