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Effect of Dietary Amino Acid Composition on the Accumulation of Lipids in the Liver of Growing Rats

Laboratory of Nutritional Biochemistry, Department of Agricultural Chemistry, Nagoya University, Chikusa, Nagoya, Japan

In an attempt to clarify the biochemical nature of the variances in the lipid content of liver of rats fed either low egg albumin or low casein diets, the effect of specific diets, consisting of amino acid mixtures which simulated egg albumin and casein and in which the level of S-containing amino acids varied, was examined. The decline in the level of S-containing amino acids (methionine and cystine) in the amino acid mixtures simulated egg albumin, causing a lowering of the liver lipids. Conversely, the high level of S-containing amino acids in the amino acid mixtures simulated casein, causing an elevation of the liver lipid content. Consequently, the dietary level of S-containing amino acids was considered to be the major factor governing the accumulation of liver lipids in rats fed the low protein diets. Our results indicate also that the ratio of methionine to cystine in the amino acid mixtures does not affect the lipid level in the liver.

Manuscript received 15 July 1968.