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Biological Activity and Excretion of the Riboflavin Analogues, 6,7-Dimethyl-9-(-Carboxyalkyl)-isoalloxazines in Rats¹

Graduate School of Nutrition and Biochemistry Section, Cornell University, Ithaca, New York

A series of 9--carboxyalkyl flavins with 3 to 6 carbon chain lengths are shown to weakly antagonize the utilization of suboptimal amounts of riboflavin in growing rats. This effect is most pronounced with the 3'-carboxypropyl compound. The 5'-¹⁴C-carboxypentyl flavin is readily excreted in the urine, and small and trace amounts of radioactivity appear in feces and CO₂, respectively. The minor breakdown of the side chain of this analogue by intestinal microflora is decreased by succinyl-sulfathiazole.

Manuscript received 29 October 1968.