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Some Relationships between Plasma, Liver and Excreta Tocopherol in Chicks Fed Graded Levels of Alpha-Tocopheryl Acetate¹

Poultry Science Department, Storrs Agricultural Experiment Station, University of Connecticut, Storrs, Connecticut

Upon feeding d-, or dl--tocopheryl acetate to chicks, at graded levels up to 2% of the diet, both plasma and liver tocopherol concentrations plateaued between dietary intakes of 667 and 3,333 mg/kg of diet when the log of the response was plotted on the log of the dietary concentration. Balance studies determined that the percentage of the tocopheryl acetate intake, which was excreted as the ester, increased sharply between the same dietary tocopherol intakes that the plasma and liver tocopherol concentrations began to plateau. At a dietary tocopherol intake of 2%, approximately 75% of the tocopheryl acetate was excreted as the intact ester. Log plasma tocopherol concentrations, when plotted on log liver tocopherol concentrations, were linear over the entire range of dietary intakes from three experiments.

² Present address: 122 Ashland Place, Brooklyn, New York 11201.

Manuscript received 12 September 1968.