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Influence of Altered Thyroid Status on the Food Intake and Growth of Rats Fed a Thiamine-deficient Diet^1,2,

Department of Nutrition and Food Science, Massachusetts Institute of Technology, Cambridge, Massachusetts

Hypothyroidism, produced by the feeding of propylthiouracil, stimulates the food intake and growth of rats fed a thiamine-deficient diet. In contrast, hyperthyroidism, produced by the administration of thyroxine, exacerbates the growth retardation of rats fed a thiamine-deficient diet without affecting the food intake. Since thiamine deficiency per se causes mild thyroid atrophy, it is postulated that thyroid function is an integral part of a feedback mechanism controlling food intake in thiamine deficiency.

² This manuscript is contribution no. 1353 from the Department of Nutrition and Food Science, Massachusetts Institute of Technology, Cambridge.

³ Present address: Department of Poultry Husbandry, University of California at Berkeley, California.

Manuscript received 9 August 1968.