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Amylase Synthesis in Pancreas of Rats Fed Soybean Flour

Department of Nutrition, Hebrew University-Hadassah Medical School, Jerusalem, and Faculty of Agriculture, Hebrew University, Rehovoth, Israel

Fasted rats received one meal of soybean flour, either heated or unheated. After 3 hours, the pancreas of rats given the unheated flour contained considerably less amylase and produced in vitro slightly less of this enzyme than pancreas of rats given heated flour. Pancreas of nonfasted rats adapted to unheated soybean flour contained and produced less amylase than pancreas of rats adapted to heated soybean flour. A preparation of soybean trypsin inhibitor (SBTI) was injected into the duodenum of fasted rats following ligation of the pylorus. After 3 hours, less amylase was found in their pancreases than in those of controls. SBTI administered by stomach tube to pylorus-ligated rats did not decrease amylase content of pancreas. Thus, soybean trypsin inhibitors cause not only increased secretion but also decreased production of pancreatic amylase, and the stimulus is mediated through a humoral agent elicited in the duodenum.