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Dimers and Trimers of -Tocopherol: Metabolic and synthetic studies

Laboratory of Metabolism, National Heart Institute, National Institutes of Health, Bethesda, Maryland

The metabolism of -tocopherol was studied in rats and mice. Evidence has been presented for formation of dimers and trimers of -tocopherol in animals that received parenteral -tocopherol. These products were shown to be identical with synthetic products of oxidative condensation of -tocopherol. The structure of these synthetic compounds was extensively studied by gas-liquid chromatography and mass spectrometry providing evidence of the necessity for modification of previously proposed structures. Dimers and trimers were not demonstrable after oral administration of -tocopherol to rats. It is suggested that oxidative condensation does not represent a quantitatively important metabolic pathway under physiological conditions.