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Journal of Nutrition Vol. 97 No. 2 February 1969, pp. 181-184
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Whole-body Retention of Strontium-85 in Swine Given Sodium Alginate or Barium and Sodium Sulfates1

L. Milin2 and J. J. B. Anderson

Department of Veterinary Physiology and Pharmacology, College of Veterinary Medicine, University of Illinois, Urbana, Illinois

Dry sodium alginate was given orally to immature and mature swine 10 minutes following oral administration of strontium-85. The whole-body retention of radiostrontium was higher in treated pigs, but was not statistically different from that of control animals. The ineffectiveness of sodium alginate may be attributable to a tough coating of alginic acid which is reported to form around dry sodium alginate in dilute acid, presumably making the alginate unavailable for metal binding. A barium sulfate and sodium sulfate mixture, given orally to pigs 10 minutes following oral administration of strontium-85, significantly decreased whole-body retention of radiostrontium in young swine; on day 1, only in older pigs. Whole-body strontium-85 retention in young pigs given the sulfate mixture was significantly less than that of control swine through day 10 following oral radioactivity dosing. Differences in the whole-body retention of strontium-85 on day 3 and day 10 following oral administration of the radionuclide were not significant in treated and control mature swine, indicating that treatment need not be repeated in mature swine, but might be warranted in young animals.

1 Supported in part by U.S. Atomic Energy Commission Contract no. AT (11-1)-1339.

2 Present address: Food and Drug Administration, Department of National Health and Welfare, Ottawa, Ontario, Canada.

Manuscript received 12 September 1968.




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