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Fluoride Toxicity in the Mouse¹

Poultry Science Department, University of Arizona, Tucson, Arizona

Young, growing mice were fed diets containing six different levels of added fluoride; only the two highest (1500 and 2000 ppm) had any effect on either growth or mortality. A dietary level of 1500 ppm fluoride was required to cause a statistically significant growth reduction. When a dietary level of 2000 ppm was fed, 100% mortality occurred. No alteration was found in the apparent digestion of either energy, fat or protein due to fluoride feeding. Examination of numerous bones showed citric acid levels to be lowered, while tibia bone fluoride concentrations were elevated. The tibia fluoride concentrations in mice fed either 1000 or 1500 ppm of added fluoride were 45 times those of the control mice. Liver homogenates were analyzed for enzyme activities, and both cytochrome oxidase and isocitric dehydrogenase activities were lowered by both the 1000 and 1500 ppm levels of fluoride. The cytochrome oxidase activity of heart tissue was reduced only with 1500 ppm fluoride in the diet.

Manuscript received 29 June 1968.