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Journal of Nutrition Vol. 97 No. 1 January 1969, pp. 79-84
Copyright © 1969 by American Society for Nutrition
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Further Studies on Growth and Feed Utilization in Progeny of Underfed Mother Rats1,2,

Boon-Nam Blackwell, R. Quentin Blackwell, Thomas T. S. Yu, Yih-Shyong Weng and Bacon F. Chow

Department of Biochemistry, U. S. Naval Medical Research Unit no. 2, Taipei, Taiwan, Republic of China, and Department of Biochemistry, School of Hygiene and Public Health, The Johns Hopkins University, Baltimore, Maryland

Previous studies have demonstrated growth-stunting and metabolic derangements, including reduced feed efficiency, in progeny of McCollum strain rat dams restricted to 50% dietary intake during gestation and lactation. These effects now have been duplicated in rats of the Sprague-Dawley strain. In addition, fostering techniques have allowed separate evaluation of the effects of maternal dietary restriction during gestation alone, and their comparison with the effect produced during the combined periods of gestation and lactation. Our results show, as suggested in earlier works, that restriction during gestation alone has a similar though perhaps lesser effect than restriction during gestation and lactation.


1 This work was accomplished under the Bureau of Medicine and Surgery Work Unit MR005. 09-0076 and was supported in part by funding from the Advanced Research Projects Agency (Project AGILE) monitored by the Nutrition Section, Office of International Research, NIH/HEW, under ARPA Order 580, Program Plan no. 298, and in part by the Bureau of Medicine and Surgery, Department of the Navy, Washington, D. C.

2 The opinions and assertions contained herein are those of the authors and are not to be construed as official or reflecting the views of the U. S. Navy Department or the U. S. Naval Service at large.

Manuscript received 9 December 1967.





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