QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Tennant, B. Articles by Goldman, M. Search for Related Content PubMed PubMed Citation Articles by Tennant, B. Articles by Goldman, M.

Influence of Microorganisms on Intestinal Absorption: Oleic Acid ¹³¹I and Triolein ¹³¹I Absorption by Germfree and Conventionalized Rats^1,2,

Department of Clinical Sciences and the Radiobiology Laboratory, School of Veterinary Medicine, University of California, Davis, California

Several differences in lipid metabolism have been demonstrated between germfree and conventional rats. To evaluate the role which intestinal absorption might play in determining these differences, we compared the absorption of oleic acid ¹³¹I and triolein ¹³¹I in germfree and conventionalized rats. Gastric emptying of both compounds appeared to be delayed in germfree rats and correspondingly less radioactivity reached the cecum during the 6-hour period following intragastric administration. When corrections were made for differences in gastric emptying, germfree and conventionalized rats absorbed oleic acid and triolein at similar rates. Under the conditions of our studies, intestinal microorganisms did not appear to influence the rate of either lipolysis or fatty acid absorption directly, but significantly influenced the rate at which fat was transported along the gastrointestinal tract.

² A preliminary report of these results was presented at the annual meeting of the Association for Gnotobiotics, Incorporated, Buffalo, New York, June 9–10, 1968.

Manuscript received 5 August 1968.