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Journal of Nutrition Vol. 97 No. 1 January 1969, pp. 61-64
Copyright © 1969 by American Society for Nutrition
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Serum Proteins in Guinea Pig Scurvy1

N. P. Torre2 and F. A. Green2

Buffalo General Hospital and Department of Medicine, State University of New York at Buffalo, Buffalo, New York

Reported changes in gamma globulin levels in guinea pig scurvy have differed, in part reflecting the type of controls used. The present study, undertaken to investigate serum protein changes in guinea pig scurvy, and to correlate these with the possible development of amyloidosis, showed no differences in gamma globulin levels between the experimental group and the controls. A constant finding was a decrease in serum albumin and an increase in alpha-1 globulin. Amyloidosis did not develop. Immunological procedures to study the development of scurvy-specific serum antigenic determinants were negative.

1 Supported in part by Public Health Service Research Grant no. AM-05581 and United Health Foundation of Western New York Research Training Grant no. F-64-BGH-1.

2 Present address: Veterans Administration Hospital, 3495 Bailey Avenue, Buffalo, New York.

Manuscript received 10 June 1968.




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