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Whole-body Retention, Tissue Distribution and Excretion of Selenium-75 after Oral and Intravenous Administration in Lambs Fed Varying Selenium Intakes^1,2,

Department of Animal Husbandry, University of Missouri, Columbia, Missouri

Selenium metabolism was studied by measuring whole-body retention, urine and fecal losses and retention in selected tissues following administration of ⁷⁵Se to lambs fed varying levels of dietary selenium. Whole-body loss of ⁷⁵Se 48 to 336 hours after administration of the isotope could be described by a first-order rate constant which was inversely proportional to the dietary level of selenium. Intravenous injection of ⁷⁵Se resulted in a higher retention than oral administration, especially on low dietary intakes of selenium. The concentration of ⁷⁵Se in various tissues was inversely related to the dietary selenium level. Kidney and liver tissue were consistently higher in ⁷⁵Se concentration than any other internal organ tissue. Of the total ⁷⁵Se dose administered, the carcass retained the highest amount, being indirectly proportional to the dietary selenium level. The major pathways of ⁷⁵Se excretion are the feces and urine. The kidney exhibited an unlimited ability to excrete ⁷⁵Se. Since a significant amount of ⁷⁵Se excretion was not accounted for as urine and fecal loss, respiratory loss of volatile selenium products formed in the rumen is offered as a possible explanation. Relative importance of these three excretory pathways depended upon dietary selenium intake level and route of ⁷⁵Se administration.

² Part of doctoral dissertation of the senior author, Department of Animal Husbandry, University of Missouri, Columbia, Missouri 65201.

Manuscript received 31 May 1968.