Journal of Nutrition

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Journal of Nutrition Vol. 97 No. 1 January 1969, pp. 109-116
Copyright © 1969 by American Society for Nutrition
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Factors Affecting Vitamin B6 Requirement in the Rat as Determined by Erythrocyte Transaminase Activity1 ,2

Ofelia V. Dirige3 and John R. Beaton

Department of Food and Nutritional Sciences, University of Hawaii, Honolulu, Hawaii

The sensitivity of erythrocyte glutamic-pyruvic transaminase (GPT) activity for assessment of vitamin B6 nutriture was demonstrated by a significant correlation between vitamin intake and GPT activity. The effects of dietary calorie, protein and amino acid intakes on vitamin B6 requirement were investigated in male rats using erythrocyte GPT activity as a criterion of vitamin B6 nutriture. There was no significant difference in erythrocyte GPT activity between hypothalamic-hyperphagic and control rats indicating that an excessive calorie intake does not alter apparent vitamin B6 requirement. With a 40-µg pyridoxine intake daily, there was a decrease in erythrocyte GPT activity as the level of protein in the diet increased, indicating that vitamin B6 requirement is apparently related to the level of dietary protein. Neither amino acid imbalance (8% casein + 15% gelatin) nor methionine toxicity (8% casein + 3% DL-methionine) appeared to alter vitamin B6 requirement as judged by erythrocyte GPT activity.

1 Supported in part by a grant from the Office of Research Administration, University of Hawaii.

2 Published with the approval of the Director, Hawaii Agricultural Experiment Station as Technical Paper no. 990.

3 Based upon a thesis submitted by Ofelia V. Dirige in partial fulfillment of the requirements for the M.S. degree at the University of Hawaii.

Manuscript received 25 July 1968.




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