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Utilization of Carotene, Vitamin A and Triglyceride Following Oral Intake of Triton

Research Laboratories, Food and Drug Directorate, Department of National Health and Welfare, Ottawa, Canada

Triton has been suggested as a nutritional adjunct to modify the absorption of fat. The postulated mode of action implied that metabolism of the fat-soluble vitamins might also be impaired. Experiments were conducted with rats to study the effects of dietary Triton WR-1339 on the utilization of ß-carotene, vitamin A, trioleate and oleic acid. The absorption of vitamin A and utilization of the provitamin were not impaired by the prefeeding of Triton. Triton did not alter the radioactivity in blood, liver or depot fat following oral administration of ¹⁴C-triolein or ¹⁴C-oleic acid. The data suggest that Triton WR-1339 at levels below 5% has little practical significance for inducing a controllable steatorrhea.