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Journal of Nutrition Vol. 96 No. 4 December 1968, pp. 499-504
Copyright © 1968 by American Society for Nutrition
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Inhibitory Effects of Alcohol on Intestinal Amino Acid Transport in vivo and in vitro1

Y. Israel, I. Salazar and E. Rosenmann

Department of Biochemistry, Casilla 233, University of Chile, Santiago, Chile

The effect of ethanol on the active transport of amino acids in the rat intestine was studied in vitro and in vivo. It was shown that 0.5 and 2.0% ethanol significantly inhibited the active transport of L-phenylalanine in everted sacs in vitro by 60 and 84%, respectively. The latter concentration completely abolished the active transport of L-methionine. At this concentration ethanol reduced tissue respiration by only 19%. In studies in vivo, 250 mg alcohol/100 g body weight given by stomach tube significantly inhibited the intestinal absorption of L-phenylalanine by about 50% but did not modify absorption of D-phenylalanine, an amino acid that is not actively transported. The possible significance of these findings is discussed in relation to the nutritional deficiencies and fatty liver that occur in chronic alcoholism.

1 Supported by Public Health Service Research Grants nos. NB-06872 from the National Institute of Neurological Diseases and Blindness and TW00259 from the Office of International Research, and by grants from the Alcoholism and Drug Addiction Research Foundation, Ontario, Canada, and the Foundation's Fund for Research in Psychiatry (U.S.A.).

Manuscript received 10 June 1968.


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E. A. Carter, G. D. Drummey, and K. J. Isselbacher
Ethanol Stimulates Triglyceride Synthesis by the Intestine
Science, December 17, 1971; 174(4015): 1245 - 1247.
[Abstract] [PDF]


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