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Journal of Nutrition Vol. 96 No. 4 December 1968, pp. 445-449
Copyright © 1968 by American Society for Nutrition
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4-Methylthiazole-5-Acetic Acid — A Urinary Metabolite of Thiamine1

M. R. Ariaey-Nejad2,3 and W. N. Pearson

Division of Nutrition, Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee

A compound identified as 4-methylthiazole-5-acetic acid (TAA) has been isolated from the urine of rats receiving injections of either 142C-thiazole-labeled thiamine or 142C-thiazole-labeled oxythiamine. Rats injected daily for 8 to 20 weeks with 40 µg of 14C-thiamine excreted 9.5% of their daily dose as TAA. Rats injected daily with 80 µg of 14C-oxythiamine excreted 12.1% of their daily dose as TAA. Rats injected with 80 µg oxythiamine + 40 µg 14C-thiamine excreted only 3.9% of their daily intake as TAA suggesting that oxythiamine inhibits this pathway of thiamine degradation.

1 Supported in part by Public Health Service Research Grant no. AM-07709 from the National Institute of Arthritis and Metabolic Diseases. Request for reprints should be directed to Dr. Pearson.

2 Present address: Imperial Iranian Army Nutrition Committee, Army Medical Department, Aziz Khan Crossroad, Hafez Avenue, Tehran, Iran.

3 A portion of these data was taken from a thesis submitted by M. R. Ariaey-Nejad to the graduate faculty of Vanderbilt University in partial fulfillment of the requirements for the degree of Doctor of Philosophy in Biochemistry.

Manuscript received 18 May 1968.




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