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Effect of Sorbitol, Fructose, Succinate, Aspartate, Glutamate and Fat on Growth and Survival Time of Biotin-deficient Rats^1,2,

Division of Nutritional Biochemistry, Department of Animal Science, University of Illinois, Urbana, Illinois

In a series of experiments (randomized complete block design) using weanling male rats, the effect of sorbitol, fructose, sodium succinate, aspartate and glutamate at a level of 5 or 10% (at the expense of glucose in the basal diet containing 20% spray-dried egg white) on growth and survival time of biotin-deficient rats was studied. The test substance was included at the beginning of the experiment or after 4 weeks on the basal diet. Under these conditions no significant effect on growth or survival time of biotin-deficient rats was observed. Addition of 10 or 20% fat to the basal diet containing 4% corn oil resulted in a significant increase in growth and survival time of deficient animals.

² Preliminary report was made at the 52nd Annual Meeting of the Federation of American Societies for Experimental Biology, 1968 Federation Proc., 27: 554 (abstract).

Manuscript received 13 May 1968.