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Rat Assay of a Simulated Human Diet for Antithyrotoxic Substances¹

Biochemistry Department and Dietetic Service of the Adult Clinical Research Center, State University of New York Upstate Medical Center at Syracuse, New York

Since certain dietary substances markedly alter the turnover and utilization of thyroid hormone in the rat, it is important to determine whether the same substances also affect thyroid hormone metabolism in the human. To conduct such a study, it is necessary to devise a diet that is very low in antithyrotoxic substances, and to find suitable foodstuffs that are high in antithyrotoxic activity. To this end, a simulated human diet was prepared and fed to rats given exogenous thyroxine (T₄). The diet was very low in antithyrotoxic activity, and the inclusion of liver, milk, beef and fish into the diet afforded the same protection against the physiological effectiveness of T₄ as liver residue, a commercial liver preparation, known to have high antithyrotoxic substance activity. Based on these results, it should be possible to prepare human diets both low and high in antithyrotoxic substance activity, and to determine the importance of these substances in human thyroid hormone metabolism and economy.

Manuscript received 27 April 1968.