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Preliminary Study of Carbohydrates in the Urine of Manganese-deficient Guinea Pigs at Birth¹

Department of Nutrition, University of California, Davis, California

Carbohydrate components of urine of manganese-deficient and control newborn guinea pigs have been determined before the animals had access to extrauterine nourishment. Small amounts of the sugars arabinose, fructose, fucose, galactose, glucose, lactose, mannose, ribose and xylose were found in the urine of newborn guinea pigs of both manganese-deficient and control dams. Equating urine specimens on the basis of creatinine concentration revealed that slightly higher amounts of ribose occurred in the manganese-deficient progeny. The most striking difference in the carbohydrate components of urine was a threefold higher concentration of free myoinositol in the urine of control animals at birth. Compounds were determined by paper chromatography techniques. Some speculation is made about the reduced myoinositol content of urine of manganese-deficient young, the synthesis of glucuronic acid in fetal development, and the relation of these to connective tissue defects known to occur in manganese-deficient guinea pigs.

^* Present address: Department of Home Economics, University of Texas, Austin, Texas.

Manuscript received 17 May 1968.