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Journal of Nutrition Vol. 96 No. 2 October 1968, pp. 206-214
Copyright © 1968 by American Society for Nutrition
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Catabolism of 14C-Thiazole-labeled Oxythiamine and Its Effects on Thiamine Catabolism in the Rat1

M. R. Ariaey-Nejad2,3 and W. N. Pearson

Division of Nutrition, Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee

The metabolism of oxythiamine and its effects on thiamine metabolism were studied. Three groups of six rats each were injected daily with 40 µg 14C-thiamine, 40 µg 14C-thiamine + 80 µg oxythiamine, or 40 µg thiamine + 80 µg 14C-oxythiamine. Injections were continued for 8 to 20 weeks after which time the urinary excretions of thiamine and oxythiamine metabolites were studied. Under these conditions oxythiamine was less susceptible to destruction by opening of the thiazole ring than was thiamine. Oxythiamine was poorly retained by the rat tissue but enhanced the excretion of thiamine. Injection of somewhat higher oxythiamine-to-thiamine ratios (4:1, 6:1) resulted in a decrease in the amount of 14CO2 generated from thiamine and the urinary excretion of thiamine and its metabolites. Higher ratios (8:1, 10:1) had less effect. Oxythiamine yielded only about half as many urinary metabolites as thiamine. One product of oxythiamine metabolism appears to be thiamine itself but the amount converted is extremely low and is of no apparent benefit to the rat.

1 Supported by Public Health Service Grant no. AM-07709. Reprint requests should be addressed to Dr. Pearson.

2 A portion of these data was taken from a thesis submitted by M. R. Ariaey-Nejad to the graduate faculty of Vanderbilt University in partial fulfillment of the requirements for the degree of Doctor of Philosophy in Biochemistry.

3 Present address: Iranian Army Nutrition Committee, Army Medical Department, Tehran, Iran.

Manuscript received 18 May 1968.




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