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Journal of Nutrition Vol. 96 No. 1 September 1968, pp. 53-59
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Cellular Antibody Synthesis in Vitamin B6-deficient Rats1

Mahendra Kumar and A. E. Axelrod

Department of Biochemistry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania

Cellular antibody synthesis was determined by the Jerne agar-plaque technique in normal and vitamin B6-deficient rats immunized with sheep erythrocytes. A severe reduction in the number of individual antibody-forming cells was observed in spleens from immunized deficient animals. This decreased cellular immune response was independent of the inanition associated with the deficiency and was restored to normal by the administration of pyridoxine shortly before immunization. Accumulation of antigen by rat spleen did not appear to be deranged in vitamin B6 deficiency.

1 This study was aided by Public Health Service Research Grant no. A-727 from the National Institute of Arthritis and Metabolic Diseases, by Office of Naval Research Contract no. NOO14-66-CO-125 and by the Health Research and Service Foundation, Pittsburgh, Pennsylvania.

Manuscript received 1 April 1968.




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