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Effect of N-(-Methylbenzyl) Linoleamide on Lipid Levels of Plasma and Liver in Cholesterol-fed Rats

Research Department, Pharmaceuticals Division, Sumitomo Chemical Company, Ltd., Osaka, Japan

Cholesterol-lowering effect of N-(-methylbenzyl) linoleamide (MBLA) was studied in rats fed cholesterol for 8 weeks and compared with that of N-cyclohexyl linoleamide (CHLA). By addition of 0.2, 0.1 or 0.05% of MBLA or 0.2% of CHLA to the cholesterol diet, the elevation of plasma cholesterol levels was markedly depressed and the deposition of lipids in the liver was also depressed. The estimated potency of MBLA was about 6.5-fold of that of CHLA with respect to plasma-liver cholesterol pools. The mixture of linoleic acid and -methyl benzylamine (1:1, by molecular weight) did not show any significant effect on plasma and liver lipid levels.