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Journal of Nutrition Vol. 95 No. 4 August 1968, pp. 633-638
Copyright © 1968 by American Society for Nutrition
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Dietary Carbohydrate and Serum Cholesterol in Rats1

Herbert W. Staub and Reinhardt Thiessen, Jr.

General Foods Technical Center, Tarrytown, New York2

The influence of various dietary carbohydrates on serum cholesterol in rats was studied with hypercholesterolemic diets containing a variety of carbohydrates. Experiments with sucrose, pregelatinized potato starch, glucose and fructose confirmed that animals fed sucrose had higher serum cholesterol levels than those fed starch and that animals fed glucose did not vary significantly from those fed starch. In experiments with carbohydrates of various chain lengths including 3 pregelatinized starches, 3 disaccharides and 2 monosaccharides, the shorter the chain length the higher the serum cholesterol level. Monosaccharides are an exception. The monosaccharide exception may be glucose alone, with only carbohydrates containing other than glucose units being hypercholesterolemic. With several different mixtures of starch and sucrose as the dietary carbohydrate, regression analysis of serum cholesterol showed a linear relation of significant slope. The larger the proportion of dietary sucrose, the higher the serum cholesterol.

1 Presented in part at the Annual Meeting of the American Institute of Nutrition, Chicago, 1967.

2 Mailing Address: General Foods Technical Center, White Plains, New York 10602.

Manuscript received 20 November 1967.


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H. W. Staub, G. Reussner, and R. Thiessen Jr.
Serum Cholesterol Reduction by Chromium in Hypercholesterolemic Rats
Science, November 7, 1969; 166(3906): 746 - 747.
[Abstract] [PDF]


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